Stearoyl–CoA desaturase (SCD) is a central lipogenic enzyme catalyzing the synthesis of
monounsaturated fatty acids, mainly oleate (C18:1) and palmitoleate (C16:1), which are …

Adipose tissue can undergo rapid expansion during times of excess caloric intake. Like a
rapidly expanding tumor mass, obese adipose tissue becomes hypoxic due to the inability of …

The discovery of autosomal dominant hypercholesterolemic patients with mutations in the
PCSK9 gene, encoding the proprotein convertase NARC-1, resulting in the missense …

Stearoyl-CoA desaturase (SCD) is a microsomal enzyme required for the biosynthesis of
oleate and palmitoleate, which are the major monounsaturated fatty acids of membrane …

Stearoyl-CoA desaturase (SCD) is expressed at high levels in several human tissues and is
required for the biosynthesis of oleate (18:1) and palmitoleate (16:1). These …

Obesity is strongly correlated with type 2 diabetes mellitus, a common disorder of glucose and
lipid metabolism. Although adipocytes are critical in obesity, their role in diabetes has only …

Histone-modifying enzymes regulate transcription and are sensitive to availability of endogenous
small-molecule metabolites, allowing chromatin to respond to changes in environment. …

Insulin resistance is necessary but not sufficient for the development of type 2 diabetes.
Diabetes results when pancreatic beta-cells fail to compensate for insulin resistance by …

The identification of mutations in ABCA1 in patients with Tangier disease and familial HDL
deficiency demonstrated that inadequate transport of phospholipid and cholesterol to the …

Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and
promote the development of cardiovascular disease (CVD) and diabetes. Recent genome-wide …