The peptide hormone leptin regulates food intake, body mass, and reproductive function and
plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis…

Serum albumin (SA) is the most abundant plasma protein in mammals. SA is a multifunctional
protein with extraordinary ligand binding capacity, making it a transporter molecule for a …

Although details of the molecular mechanisms for the uptake of the essential nutrient zinc into
the bloodstream and its subsequent delivery to zinc-requiring organs and cells are poorly …

Albumin is the major transport protein in blood for Zn 2+ , a metal ion required for physiological
processes and recruited by various drugs and toxins. However, the Zn 2+ -binding site(s) …

Type 2 diabetes mellitus (T2DM) is associated with increased total plasma free fatty acid (FFA)
concentrations and an elevated risk of cardiovascular disease. The exact mechanisms by …

Most blood plasma zinc is bound to albumin, but the structure of the binding site has not
been determined. Zn K-edge extended x-ray absorption fine structure spectroscopy and …

Human PHOSPHO1 is a phosphatase enzyme for which expression is upregulated in
mineralizing cells. This enzyme has been implicated in the generation of P i for matrix …

Cys34 in domain I of the three‐domain serum protein albumin is the binding site for a wide
variety of biologically and clinically important small molecules, provides antioxidant activity, …

Mineralisation of bone and cartilage is essential for skeletal development and function. We
have previously reported a novel gene (PHOSPHO1); a member of the large haloacid …

GPR39 is a vertebrate G protein-coupled receptor related to the ghrelin/neurotensin receptor
subfamily. The receptor is expressed in a range of tissues including the pancreas, gut/…