[HTML][HTML] Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

…, P Eickhoff, A Early, A Nans, AMC Cheung… - Nature …, 2018 - nature.com
Eukaryotic origin firing depends on assembly of the Cdc45-MCM-GINS (CMG) helicase. A
key step is the recruitment of GINS that requires the leading-strand polymerase Pol epsilon, …

Do racial or socioeconomic disparities exist in lung cancer treatment?

R Yang, MC Cheung, MM Byrne, Y Huang, D Nguyen… - Cancer, 2010 - Wiley Online Library
BACKGROUND: Determine the effects of race, socioeconomic status, and treatment on
outcomes for patients diagnosed with lung cancer. METHODS: The Florida cancer registry and …

[HTML][HTML] Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease

…, A Chait, LD Fisher, MC Cheung… - … England Journal of …, 2001 - Mass Medical Soc
Background Both lipid-modifying therapy and antioxidant vitamins are thought to have
benefit in patients with coronary disease. We studied simvastatin–niacin and antioxidant-vitamin …

African American and poor patients have a dramatically worse prognosis for head and neck cancer: an examination of 20,915 patients

MA Molina, MC Cheung, EA Perez, MM Byrne… - Cancer, 2008 - Wiley Online Library
BACKGROUND. Differences in cancer survival based on race, ethnicity, and socioeconomic
status (SES) are a major issue. To identify points of intervention and improve survival, the …

[HTML][HTML] Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL

…, SA Gharib, AN Hoofnagle, MC Cheung… - The Journal of …, 2007 - Am Soc Clin Investig
HDL lowers the risk for atherosclerotic cardiovascular disease by promoting cholesterol
efflux from macrophage foam cells. However, other antiatherosclerotic properties of HDL are …

Are patients of low socioeconomic status receiving suboptimal management for pancreatic adenocarcinoma?

MC Cheung, R Yang, MM Byrne… - … Journal of the …, 2010 - Wiley Online Library
BACKGROUND: The objective of this study was to define the effects of socioeconomic
status (SES) and other demographic variables on outcomes for patients with pancreatic …

Bortezomib in multiple myeloma: systematic review and clinical considerations

…, AE Haynes, K Imrie, DE Reece, MC Cheung - Current oncology, 2014 - mdpi.com
We conducted a systematic review to determine the appropriate use of bortezomib alone or
in combination with other agents in patients with multiple myeloma (MM). We searched …

Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL

MC Cheung, XQ Zhao, A Chait, JJ Albers… - … , and vascular biology, 2001 - Am Heart Assoc
One strategy for treating coronary artery disease (CAD) patients with low HDL cholesterol (HDL-C)
is to maximally increase the HDL-C to LDL-C ratio by combining lifestyle changes …

TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory

KO Lai, ASL Wong, MC Cheung, P Xu, Z Liang… - Nature …, 2012 - nature.com
The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor TrkB participate
in diverse neuronal functions, including activity-dependent synaptic plasticity that is crucial …

Defining the role of surgery for primary gastrointestinal tract melanoma

MC Cheung, EA Perez, MA Molina, X Jin… - Journal of …, 2008 - Elsevier
Objective The objective of the study was to determine the outcomes for primary gastrointestinal
melanomas (PGIM). Material and methods The Surveillance, Epidemiology, and End …