Huntington's disease is caused by an abnormally long polyglutamine tract in the huntingtin
protein. This leads to the generation and deposition of N-terminal exon1 fragments of the …

Affinity chromatography is likely to play an increasingly important role in the purification of
pharmaceutical proteins. This review describes new approaches to the design and synthesis …

10.7554/eLife.12620.001 Bacterial phototaxis was first recognized over a century ago, but
the method by which such small cells can sense the direction of illumination has remained …

The Nuclear Pore Complex (NPC) is the selective filter that facilitates all exchange between
the cytoplasm and the nucleus in eukaryotic cells, allowing small molecules to passively …

10.7554/eLife.04052.001 Soluble karyopherins of the importin-β (impβ) family use RanGTP
to transport cargos directionally through the nuclear pore complex (NPC). Whether impβ or …

Mitochondrial Rho (Miro) GTPases localize to the outer mitochondrial membrane and are
essential machinery for the regulated trafficking of mitochondria to defined subcellular locations…

Repeat proteins are ubiquitous and are involved in a myriad of essential processes. They
are typically non-globular structures that act as diverse scaffolds for the mediation of protein–…

The subunits of the presumptive replicative helicase of archaea and eukaryotes, the MCM
complex, are members of the AAA+ (ATPase-associated with various cellular activities) family …

Single-cell methods are beginning to reveal the intrinsic heterogeneity in cell populations,
arising from the interplay of deterministic and stochastic processes. However, it remains …

Deep learning is now a powerful tool in microscopy data analysis, and is routinely used for
image processing applications such as segmentation and denoising. However, it has rarely …