The receptor for the epidermal growth factor (EGF) and related ligands (EGFR), the prototypal
member of the superfamily of receptors with intrinsic tyrosine kinase activity, is widely …

Cell migration on 2D surfaces is governed by a balance between counteracting tractile and
adhesion forces. Although biochemical factors such as adhesion receptor and ligand …

Integrin adhesion receptors play a crucial role in regulating interactions between cells and
extracellular matrix (ECM). Integrin activation initiates multiple intracellular signaling …

Phagocytosis requires localized and transient remodeling of actin filaments. Phosphoinositide
signaling is believed to play an important role in cytoskeletal organization, but it is unclear …

Good-genes hypotheses of sexual selection predict that offspring fathered by preferred males
should have increased viability resulting from superior genetic quality. Several studies of …

Background Epithelial to mesenchymal transition (EMT), implicated as a mechanism for tumor
dissemination, is marked by loss of E-cadherin, disruption of cell adhesion, and induction …

Calpains are a large family of intracellular proteases whose precise and limited cleavage of
specific proteins might be an integral regulatory aspect of signaling pathways. This intriguing …

Cancer metastasis follows a sequential series of events, and many of the critical steps are
distinctly similar to EMT-like transformations that occur during normal embryonic development. …

As yet, there is no cure for metastatic breast cancer. Historically, considerable research
effort has been concentrated on understanding the processes of metastasis, how a primary …

Identification of a mutant epidermal growth factor (EGF) receptor that does not undergo
downregulation has provided a genetic probe to investigate the role of internalization in ligand-…