User profiles for Alan Y. Hsu
 | Alan Y. HsuHarvard Medical School/Boston Children's Hospital Verified email at childrens.harvard.edu Cited by 499 |
Enzyme-responsive peptide thioesters for targeting Golgi apparatus
…, MC Quiñones-Frías, AY Hsu, Y Zhang… - Journal of the …, 2022 - ACS Publications
The Golgi apparatus (GA) is the hub of intracellular trafficking, but selectively targeting GA
remains a challenge. We show an unconventional types of peptide thioesters, consisting of an …
remains a challenge. We show an unconventional types of peptide thioesters, consisting of an …
miRNA-223 at the crossroads of inflammation and cancer
miR-223 is an evolutionarily conserved anti-inflammatory microRNA primarily expressed in
myeloid cells. miR-223 post-transcriptionally regulates many genes essential in inflammation…
myeloid cells. miR-223 post-transcriptionally regulates many genes essential in inflammation…
Palmitoylation of gasdermin D directs its membrane translocation and pore formation in pyroptosis
Gasdermin D (GSDMD)-mediated macrophage pyroptosis plays a critical role in inflammation
and host defense. Plasma membrane perforation elicited by caspase-cleaved GSDMD N-…
and host defense. Plasma membrane perforation elicited by caspase-cleaved GSDMD N-…
Chemically-defined generation of human hemogenic endothelium and definitive hematopoietic progenitor cells
Human hematopoietic stem cells (HSCs), which arise from aorta-gonad-mesonephros (AGM),
are widely used to treat blood diseases and cancers. However, a technique for their robust …
are widely used to treat blood diseases and cancers. However, a technique for their robust …
Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration
Neutrophil migration is essential for inflammatory responses to kill pathogens; however,
excessive neutrophilic inflammation also leads to tissue injury and adverse effects. To discover …
excessive neutrophilic inflammation also leads to tissue injury and adverse effects. To discover …
[HTML][HTML] Heterogeneity of neutrophils in cancer: one size does not fit all
…, C Xu, J Li, J Zha, F Ma, HR Luo, AY Hsu - Cancer Biology & …, 2022 - ncbi.nlm.nih.gov
Neutrophils play an essential role in the defense against bacterial infections and orchestrate
both the innate and adaptive immune responses. With their abundant numbers, diverse …
both the innate and adaptive immune responses. With their abundant numbers, diverse …
NLRP3 is essential for neutrophil polarization and chemotaxis in response to leukotriene B4 gradient
Neutrophil recruitment to sites of infection and inflammation is an essential process in the
early innate immune response. Upon activation, a subset of neutrophils rapidly assembles the …
early innate immune response. Upon activation, a subset of neutrophils rapidly assembles the …
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis
Plasma membrane perforation elicited by caspase cleavage of the gasdermin D (GSDMD) N-terminal
domain (GSDMD-NT) triggers pyroptosis. The mechanisms underlying GSDMD …
domain (GSDMD-NT) triggers pyroptosis. The mechanisms underlying GSDMD …
Overexpression of microRNA-722 fine-tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish
Neutrophilic inflammation is essential for defending against invading pathogens, but can
also be detrimental in many clinical settings. The hematopoietic-specific small Rho-GTPase …
also be detrimental in many clinical settings. The hematopoietic-specific small Rho-GTPase …
The risk assessment of uveitis after COVID‐19 diagnosis: A multicenter population‐based study
Reports on uveitis after COVID‐19 have been limited. Our objective was to examine the risk
of uveitis among COVID‐19 patients. This was a retrospective cohort study based on the …
of uveitis among COVID‐19 patients. This was a retrospective cohort study based on the …