[PDF][PDF] Polyamines and eIF5A hypusination modulate mitochondrial respiration and macrophage activation
…, RL Kyle, G Caputa, D O'Sullivan, AM Cameron… - Cell metabolism, 2019 - cell.com
How cells adapt metabolism to meet demands is an active area of interest across biology.
Among a broad range of functions, the polyamine spermidine is needed to hypusinate the …
Among a broad range of functions, the polyamine spermidine is needed to hypusinate the …
[PDF][PDF] Mitochondrial integrity regulated by lipid metabolism is a cell-intrinsic checkpoint for Treg suppressive function
…, AM Cameron, DE Sanin, KL Hippen, M Loschi… - Cell metabolism, 2020 - cell.com
Regulatory T cells (Tregs) subdue immune responses. Central to Treg activation are changes
in lipid metabolism that support their survival and function. Fatty acid binding proteins (…
in lipid metabolism that support their survival and function. Fatty acid binding proteins (…
Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage
AM Cameron, A Castoldi, DE Sanin… - Nature …, 2019 - nature.com
The adoption of Warburg metabolism is critical for the activation of macrophages in response
to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase their …
to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase their …
[HTML][HTML] Triacylglycerol synthesis enhances macrophage inflammatory function
Foamy macrophages, which have prominent lipid droplets (LDs), are found in a variety of
disease states. Toll-like receptor agonists drive triacylglycerol (TG)-rich LD development in …
disease states. Toll-like receptor agonists drive triacylglycerol (TG)-rich LD development in …
[PDF][PDF] MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function
Antigenic stimulation promotes T cell metabolic reprogramming to meet increased biosynthetic,
bioenergetic, and signaling demands. We show that the one-carbon (1C) metabolism …
bioenergetic, and signaling demands. We show that the one-carbon (1C) metabolism …
[PDF][PDF] Mitochondrial membrane potential regulates nuclear gene expression in macrophages exposed to prostaglandin E2
…, MD Buck, J Qiu, SJ Lawless, AM Cameron, M Villa… - Immunity, 2018 - cell.com
Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has
been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is …
been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is …
Macrophage metabolism: a wound‐healing perspective
…, LJ Flachsmann, AM Cameron - Immunology and Cell …, 2019 - Wiley Online Library
Macrophages are a critical component of the innate immune response, and compose the
first response to perturbations in tissue homeostasis. Their unique ability to dynamically …
first response to perturbations in tissue homeostasis. Their unique ability to dynamically …
Metabolism and acetylation in innate immune cell function and fate
AM Cameron, SJ Lawless, EJ Pearce - Seminars in immunology, 2016 - Elsevier
Innate immunity is the first line of defense against invading pathogens. Changes in both
metabolism and chromatin accessibility contribute to the shaping of these innate immune …
metabolism and chromatin accessibility contribute to the shaping of these innate immune …
[PDF][PDF] Metabolic and functional remodeling of colonic macrophages in response to high-fat diet-induced obesity
…, N Rana, KM Grzes, AM Kabat, J Curtis, AM Cameron… - Iscience, 2023 - cell.com
Little is known about the effects of high-fat diet (HFD)-induced obesity on resident colonic
lamina propria (LP) macrophages (LPMs) function and metabolism. Here, we report that …
lamina propria (LP) macrophages (LPMs) function and metabolism. Here, we report that …
[HTML][HTML] DNA methylation in blood—potential to provide new insights into cell biology
D Macartney-Coxson, AM Cameron, J Clapham… - Plos one, 2020 - journals.plos.org
Epigenetics plays a fundamental role in cellular development and differentiation; epigenetic
mechanisms, such as DNA methylation, are involved in gene regulation and the exquisite …
mechanisms, such as DNA methylation, are involved in gene regulation and the exquisite …