[PDF][PDF] Polyamines and eIF5A hypusination modulate mitochondrial respiration and macrophage activation

…, RL Kyle, G Caputa, D O'Sullivan, AM Cameron… - Cell metabolism, 2019 - cell.com
How cells adapt metabolism to meet demands is an active area of interest across biology.
Among a broad range of functions, the polyamine spermidine is needed to hypusinate the …

[PDF][PDF] Mitochondrial integrity regulated by lipid metabolism is a cell-intrinsic checkpoint for Treg suppressive function

…, AM Cameron, DE Sanin, KL Hippen, M Loschi… - Cell metabolism, 2020 - cell.com
Regulatory T cells (Tregs) subdue immune responses. Central to Treg activation are changes
in lipid metabolism that support their survival and function. Fatty acid binding proteins (…

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage

AM Cameron, A Castoldi, DE Sanin… - Nature …, 2019 - nature.com
The adoption of Warburg metabolism is critical for the activation of macrophages in response
to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase their …

[HTML][HTML] Triacylglycerol synthesis enhances macrophage inflammatory function

…, DE Sanin, N Rana, M Corrado, AM Cameron… - Nature …, 2020 - nature.com
Foamy macrophages, which have prominent lipid droplets (LDs), are found in a variety of
disease states. Toll-like receptor agonists drive triacylglycerol (TG)-rich LD development in …

[PDF][PDF] MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

…, AE Sewell, SK Shahi, SN Freedman, AM Cameron… - Immunity, 2022 - cell.com
Antigenic stimulation promotes T cell metabolic reprogramming to meet increased biosynthetic,
bioenergetic, and signaling demands. We show that the one-carbon (1C) metabolism …

[PDF][PDF] Mitochondrial membrane potential regulates nuclear gene expression in macrophages exposed to prostaglandin E2

…, MD Buck, J Qiu, SJ Lawless, AM Cameron, M Villa… - Immunity, 2018 - cell.com
Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has
been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is …

Macrophage metabolism: a wound‐healing perspective

…, LJ Flachsmann, AM Cameron - Immunology and Cell …, 2019 - Wiley Online Library
Macrophages are a critical component of the innate immune response, and compose the
first response to perturbations in tissue homeostasis. Their unique ability to dynamically …

Metabolism and acetylation in innate immune cell function and fate

AM Cameron, SJ Lawless, EJ Pearce - Seminars in immunology, 2016 - Elsevier
Innate immunity is the first line of defense against invading pathogens. Changes in both
metabolism and chromatin accessibility contribute to the shaping of these innate immune …

[PDF][PDF] Metabolic and functional remodeling of colonic macrophages in response to high-fat diet-induced obesity

…, N Rana, KM Grzes, AM Kabat, J Curtis, AM Cameron… - Iscience, 2023 - cell.com
Little is known about the effects of high-fat diet (HFD)-induced obesity on resident colonic
lamina propria (LP) macrophages (LPMs) function and metabolism. Here, we report that …

[HTML][HTML] DNA methylation in blood—potential to provide new insights into cell biology

D Macartney-Coxson, AM Cameron, J Clapham… - Plos one, 2020 - journals.plos.org
Epigenetics plays a fundamental role in cellular development and differentiation; epigenetic
mechanisms, such as DNA methylation, are involved in gene regulation and the exquisite …