[HTML][HTML] Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance

…, S Henderson, H Wassall, J Brewin, A Masson… - Nature …, 2021 - nature.com
In both sickle cell disease and malaria, red blood cells (RBCs) are phagocytosed in the spleen,
but receptor-ligand pairs mediating uptake have not been identified. Here, we report that …

[HTML][HTML] Hemoglobin S induces exposure of red blood cell membrane skeleton microdomains bearing mannose that stimulate phagocytosis by macrophages: a …

…, LS Hall, HM Wilson, J Shepherd, B Patel, A Masson… - Blood, 2018 - Elsevier
Heterozygosity for Hemoglobin (Hb) S, sickle cell trait (SCT), affects over 40 million people
and confers resistance to severe infection by Plasmodium falciparum. Homozygosity for HbS, …

High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria

…, S Henderson, H Wassall, J Brewin, A Masson… - bioRxiv, 2020 - biorxiv.org
In both sickle cell disease (SCD) and malaria, red blood cells (RBCs) are phagocytosed in
the spleen, but receptor-ligand pairs mediating uptake have not been identified. Here, we …

[HTML][HTML] Evaluation of classical clinical endpoints as surrogates for overall survival in patients treated with immune checkpoint blockers: a systematic review and meta …

…, M Sznol, K Fahrbach, Y Xu, E Masson… - Journal of cancer …, 2018 - Springer
Purpose Classical clinical endpoints [eg, objective response rate (ORR), disease control rate
(DCR), and progression-free survival (PFS)] may not be appropriate for immune checkpoint …

Trauma Association of Canada Annual Scientific Meeting, Westin Calgary Calgary, Alberta, Apr. 10–11, 2015Outcomes and opportunities for improvement in self …

…, L Hewitson, C Rouse, H Al-Thani, M Masson-Trottier… - 2015 - canjsurg.ca
Background: Self-inflicted trauma (SIT) is a public health issue ranking 4th as leading cause
of death and disability in young adults. Methods: Retrospective descriptive analysis of …

The Effect of Dosing of Stromal Cell-Derived Factor 1 on Anal Sphincter Regeneration

L Sun, A Billups, A Rietsch, MS Damaser… - … Engineering Part A, 2023 - liebertpub.com
… channel alone, histopathology using Masson's trichrome, and immunohistochemistry using
PGP9.5 … Quantification of Masson-stained slides showed no statistically significant differences …

Stromal cell derived factor 1 plasmid to regenerate the anal sphincters

L Sun, A Billups, A Rietsch… - Journal of tissue …, 2022 - Wiley Online Library
The aim of this study was to evaluate regeneration of a chronic large anal sphincter defect in
a pig model after treatment with a plasmid encoding Stromal Cell Derived Factor‐1(SDF‐1). …

[HTML][HTML] Effect of resveratrol on expression of genes involved thermogenesis in mice and humans

JMO Andrade, AS Barcala-Jorge… - Biomedicine & …, 2019 - Elsevier
The present study aimed to evaluate the effects of resveratrol on FNDC5 and thermogenesis
markers expression in the adipose tissue of mice and humans. Thirty-two male mice were …

Enaminones 12. An explanation of anticonvulsant activity and toxicity per Linus Pauling's clathrate hypothesis

PL Jackson, CD Hanson, AK Farrell, RJ Butcher… - European journal of …, 2012 - Elsevier
The x-ray crystal structure of 3-((5-methylisoxazol-3-yl)amino)-5-methylcyclohex-2-enone (12b)
and 3-((5-methylisoxazolyl-3-yl)amino)-5,5-dimethylcyclohex-2-enone (12c) were …

Genome-wide association analysis identifies six new loci associated with forced vital capacity

DW Loth, MS Artigas, SA Gharib, LV Wain… - Nature …, 2014 - nature.com
Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung
volume and is used to diagnose and monitor lung diseases. We performed genome-wide …