hDM2 is recognized in vivo by a short α-helix within the p53 trans-activation domain (p53AD).
Disruption of the p53·hDM2 interaction is an important goal for cancer therapy. A functional …

Stimulated emission depletion (STED) nanoscopy allows observations of subcellular
dynamics at the nanoscale. Applications have, however, been severely limited by the lack of a …

The ecstasy of discovering a new hit from screening can lead to a highly productive research
effort to discover new bioactive compounds. However, in too many cases this ecstasy is …

Using cryo-electron microscopy (cryo-EM), we determined the structure of the Escherichia coli
70S ribosome with a global resolution of 2.0 Å. The maps reveal unambiguous positioning …

We recently reported that β-peptides can form discrete hetero-oligomers in aqueous solution.
Here we describe the structure of such an oligomer as determined by X-ray crystallography…

We became interested several years ago in exploring whether 14-helical β-peptide foldamers
could bind protein surfaces and inhibit protein–protein interactions, and if so, whether their …

There is considerable interest in novel cell imaging tools that avoid the use of fluorescent
proteins. One widely used class of such reagents are “pro-fluorescent” biarsenical dyes such …

Proteins represent an expanding class of therapeutics, but their actions are limited primarily
to extracellular targets because most peptidic molecules fail to enter cells. Here we identified …

Linear peptides derived from the HIV gp41 C-terminus (C-peptides), such as the 36-residue
Fuzeon, are potent HIV fusion inhibitors. These molecules bind to the N-peptide region of …

Imaging cellular structures and organelles in living cells by long time-lapse super-resolution
microscopy is challenging, as it requires dense labeling, bright and highly photostable dyes, …