A phenotype of Escherichia coli and Klebsiella pneumoniae, resistant to piperacillin/tazobactam
(TZP) but susceptible to carbapenems and 3rd generation cephalosporins, has emerged…

Antimicrobial resistance is a global healthcare problem with a dwindling arsenal of usable
drugs. Tuberculosis, caused by Mycobacterium tuberculosis, requires long-term combination …

Escherichia coli and other Enterobacteriaceae are diverse species with “open” pangenomes,
where genes move intra- and interspecies via horizontal gene transfer. However, most …

Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together
affect ∼157 million people and inflict severe disability. Both diseases are caused by parasitic …

Enterobacterales from livestock are potentially important reservoirs for antimicrobial resistance
(AMR) to pass through the food chain to humans, thereby increasing the AMR burden …

HT61 is a quinoline-derived antimicrobial, which exhibits bactericidal potency against both
multiplying and quiescent methicillin resistant and sensitive Staphylococcus aureus, and has …

The increased biosynthesis of lysyl-phosphatidylglycerol in Staphylococcus aureus when
cultured under conditions of mild acidity and the resultant increased proportion of this lipid in …

Pneumonia is the sixth largest cause of death in the UK. It is usually caused by Streptococcus
pneumoniae, which healthy individuals can carry in their nose without symptoms of …

The fitness cost to bacteria of acquisition of resistance determinants is critically under-investigated,
and the identification and exploitation of these fitness costs may lead to novel …

Resistance to piperacillin/tazobactam (TZP) in Escherichia coli has predominantly been
associated with mechanisms that confer resistance to third-generation cephalosporins. Recent …