Zinc (Zn) and copper (Cu) are essential for optimal innate immune function, and nutritional
deficiency in either metal leads to increased susceptibility to bacterial infection. Recently, the …

The immunomodulatory and antimicrobial properties of zinc and copper have long been
appreciated. In addition, these metal ions are also essential for microbial growth and survival. …

Neisseria gonorrhoeae is a host-adapted pathogen that colonizes primarily the human
genitourinary tract. This bacterium encounters reactive oxygen and reactive nitrogen species as a …

Transition row metal ions are both essential and toxic to microorganisms. Zinc in excess has
significant toxicity to bacteria, and host release of Zn(II) at mucosal surfaces is an important …

As a facultative aerobe with a high iron requirement and a highly active aerobic respiratory
chain, Neisseria gonorrhoeae requires defence systems to respond to toxic oxygen species …

The movement of key transition metal ions is recognized to be of critical importance in the
interaction between macrophages and intracellular pathogens. The present study investigated …

psaA encodes a 37-kDa pneumococcal lipoprotein which is part of an ABC Mn(II) transport
complex. Streptococcus pneumoniae D39 psaA mutants have previously been shown to be …

Formaldehyde is the simplest of all aldehydes and is highly cytotoxic. Its use and associated
dangers from environmental exposure have been well documented. Detoxification systems …

Catheter-associated urinary tract infection (CAUTI) is the most common nosocomial infection
in the United States. Uropathogenic Escherichia coli (UPEC), the most common cause of …

The relative stability of divalent first-row transition metal ion complexes, as defined by the
Irving-Williams series, poses a fundamental chemical challenge for selectivity in bacterial metal …