Colorectal cancer arises in individuals with acquired or inherited genetic predisposition who
are exposed to a range of risk factors. Many of these risk factors are associated with affluent …

… , the Watson score, which reflected severity of epithelial shedding and barrier loss. A Watson
… Thus, the number of shedding cells being lost is not part of Watson grade I. Evidence of loss …

Apoptosis plays an important role in homeostasis of intestinal epithelia and is also a stress
response to toxic stimuli. Transgenic and knockout mice have provided insights into the …

Epithelial paracellular barrier function, determined primarily by tight junction permeability, is
frequently disrupted in disease. In the intestine, barrier loss can be mediated by tumor …

Nonsteroidal anti-inflammatory drugs have potential for use in the prevention and/or treatment
of colorectal cancer. We have studied the cytotoxic effect of a specific COX-2 inhibitor, …

The cell-positional incidence of both spontaneous and damage-induced apoptosis of epithelial
cells was assessed in longitudinal sections of the crypts of small intestine and colon of …

Background & Aims Tumor necrosis factor (TNF) increases intestinal epithelial cell shedding
and apoptosis, potentially challenging the barrier between the gastrointestinal lumen and …

We have investigated in detail the role of intra-organelle Ca 2+ content during induction of
apoptosis by the oxidant menadione while changing and monitoring the Ca 2+ load of …

The gut barrier, composed of a single layer of intestinal epithelial cells (IECs) held together
by tight junctions, prevents the entrance of harmful microorganisms, antigens and toxins from …

Background & Aims: Confocal endomicroscopy is an emerging technology that poses the
endoscopist with challenges for identifying epithelial structures in the human intestine. We …