User profiles for Albena T. Dinkova-Kostova
 | Albena T. Dinkova-KostovaProfessor of Chemical Biology, University of Dundee Verified email at dundee.ac.uk Cited by 45519 |
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage
function, but its precise mechanism of action remains poorly understood 1 , 2 , 3 . Here we …
function, but its precise mechanism of action remains poorly understood 1 , 2 , 3 . Here we …
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
AT Dinkova-Kostova, WD Holtzclaw… - Proceedings of the …, 2002 - National Acad Sciences
Coordinate induction of phase 2 proteins and elevation of glutathione protect cells against
the toxic and carcinogenic effects of electrophiles and oxidants. All inducers react covalently …
the toxic and carcinogenic effects of electrophiles and oxidants. All inducers react covalently …
The cytoprotective role of the Keap1–Nrf2 pathway
L Baird, AT Dinkova-Kostova - Archives of toxicology, 2011 - Springer
An elaborate network of highly inducible proteins protects aerobic cells against the cumulative
damaging effects of reactive oxygen intermediates and toxic electrophiles, which are the …
damaging effects of reactive oxygen intermediates and toxic electrophiles, which are the …
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
…, TW Kensler, AT Dinkova-Kostova - Nature reviews Drug …, 2019 - nature.com
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (KEAP1)…
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (KEAP1)…
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates …
Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-inducible
expression of a battery of genes encoding key components of the glutathione-based and …
expression of a battery of genes encoding key components of the glutathione-based and …
[PDF][PDF] Oxidative stress in cancer
Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
JD Hayes, AT Dinkova-Kostova - Trends in biochemical sciences, 2014 - cell.com
Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2, also called Nfe2l2) is a transcription
factor that regulates the cellular redox status. Nrf2 is controlled through a complex …
factor that regulates the cellular redox status. Nrf2 is controlled through a complex …
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers
N Wakabayashi, AT Dinkova-Kostova… - Proceedings of the …, 2004 - National Acad Sciences
Induction of a family of phase 2 genes encoding for proteins that protect against the damage
of electrophiles and reactive oxygen intermediates is potentially a major strategy for …
of electrophiles and reactive oxygen intermediates is potentially a major strategy for …
[HTML][HTML] The emerging role of Nrf2 in mitochondrial function
AT Dinkova-Kostova, AY Abramov - Free Radical Biology and Medicine, 2015 - Elsevier
The transcription factor NF-E2 p45-related factor 2 (Nrf2; gene name NFE2L2) allows
adaptation and survival under conditions of stress by regulating the gene expression of diverse …
adaptation and survival under conditions of stress by regulating the gene expression of diverse …
NAD (P) H: quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector
AT Dinkova-Kostova, P Talalay - Archives of biochemistry and biophysics, 2010 - Elsevier
NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) is a widely-distributed FAD-dependent
flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, …
flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, …