The first step of RAF activation involves binding to active RAS, resulting in the recruitment of
RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction, …

Development of resistance remains a major challenge for drugs to treat HIV-1 infections,
including those targeting the essential viral polymerase, HIV-1 reverse transcriptase (RT). …

Staphylococcus aureus is the leading cause of hospital‐acquired infections in the U nited S
tates. The emergence of multidrug‐resistant strains of S . aureus has created an urgent need …

Localized dynamics of RAS, including regions distal to the nucleotide-binding site, is of high
interest for elucidating the mechanisms by which RAS proteins interact with effectors and …

During the activation of mitogen-activated protein kinase (MAPK) signaling, the RAS-binding
domain (RBD) and cysteine-rich domain (CRD) of RAF bind to active RAS at the plasma …

The appeal of multiscale modeling approaches is predicated on the promise of combinatorial
synergy. However, this promise can only be realized when distinct scales are combined …

Reverse transcriptase (RT) from the human immunodeficiency virus continues to be an attractive
drug target for antiretroviral therapy. June 2022 will commemorate the 30th anniversary …

The endospore forming bacterium Bacillus anthracis causes lethal anthrax disease in humans
and animals. The ability of this pathogen to replicate within macrophages is dependent …

The retrovirus HIV‐1 has been a major health issue since its discovery in the early 80s. In
2017, over 37 million people were infected with HIV‐1, of which 1.8 million were new …

Catechol diethers that incorporate a 7-cyano-2-naphthyl substituent are reported as non-nucleoside
inhibitors of HIV-1 reverse transcriptase (NNRTIs). Many of the compounds have 1–…