User profiles for Albert Y. Lau
 | Albert Y. LauAssociate Professor of Biophysics and Biophysical Chemistry, Johns Hopkins University … Verified email at jhmi.edu Cited by 3263 |
Self-assembling protein microarrays
Protein microarrays provide a powerful tool for the study of protein function. However, they
are not widely used, in part because of the challenges in producing proteins to spot on the …
are not widely used, in part because of the challenges in producing proteins to spot on the …
[HTML][HTML] Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision
DNA N-glycosylases are base excision-repair proteins that locate and cleave damaged
bases from DNA as the first step in restoring the genetic blueprint. The human enzyme 3-…
bases from DNA as the first step in restoring the genetic blueprint. The human enzyme 3-…
Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG
The human 3-methyladenine DNA glycosylase [alkyladenine DNA glycosylase (AAG)] catalyzes
the first step of base excision repair by cleaving damaged bases from DNA. Unlike other …
the first step of base excision repair by cleaving damaged bases from DNA. Unlike other …
3‐methyladenine DNA glycosylases: structure, function, and biological importance
The genome continuously suffers damage due to its reactivity with chemical and physical
agents. Finding such damage in genomes (that can be several million to several billion …
agents. Finding such damage in genomes (that can be several million to several billion …
[HTML][HTML] Detection of protein folding defects caused by BRCA1-BRCT truncation and missense mutations
…, DI Chasman, DD Hau, B Hui, AY Lau… - Journal of Biological …, 2003 - ASBMB
Most cancer-associated BRCA1 mutations identified to date result in the premature translational
termination of the protein, highlighting a crucial role for the C-terminal, BRCT repeat …
termination of the protein, highlighting a crucial role for the C-terminal, BRCT repeat …
[PDF][PDF] Conformational analysis of NMDA receptor GluN1, GluN2, and GluN3 ligand-binding domains reveals subtype-specific characteristics
The NMDA receptor family of glutamate receptor ion channels is formed by obligate
heteromeric assemblies of GluN1, GluN2, and GluN3 subunits. GluN1 and GluN3 bind glycine, …
heteromeric assemblies of GluN1, GluN2, and GluN3 subunits. GluN1 and GluN3 bind glycine, …
[PDF][PDF] The hidden energetics of ligand-binding and activation in a glutamate receptor
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the
majority of excitatory synaptic transmission in the central nervous system. The free energy of …
majority of excitatory synaptic transmission in the central nervous system. The free energy of …
[PDF][PDF] The free energy landscapes governing conformational changes in a glutamate receptor ligand-binding domain
Ionotropic glutamate receptors are ligand-gated transmembrane ion channels activated by
the binding of glutamate. The free energy landscapes governing the opening/closing of the …
the binding of glutamate. The free energy landscapes governing the opening/closing of the …
[HTML][HTML] Conformational changes in the essential E. coli septal cell wall synthesis complex suggest an activation mechanism
The bacterial divisome is a macromolecular machine composed of more than 30 proteins
that controls cell wall constriction during division. Here, we present a model of the structure …
that controls cell wall constriction during division. Here, we present a model of the structure …
[PDF][PDF] Glutamate and glycine binding to the NMDA receptor
At central nervous system synapses, agonist binding to postsynaptic ionotropic glutamate
receptors (iGluRs) results in signaling between neurons. N-Methyl-D-aspartic acid (NMDA) …
receptors (iGluRs) results in signaling between neurons. N-Methyl-D-aspartic acid (NMDA) …