User profiles for Alberto Alape

Alberto Alape-Girón

Universidad de Costa Rica
Verified email at ucr.ac.cr
Cited by 4039

Characterization of 'basparin A,'a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces …

…, AS Kamiguti, RDG Theakston, JW Fox, A Alape… - Archives of biochemistry …, 2003 - Elsevier
A prothrombin activator, named ‘basparin A,’ was isolated from the venom of the crotaline
snake Bothrops asper, the species responsible for the majority of snakebite cases in Central …

[HTML][HTML] Development and characterization of two equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19

…, R Sanchez, JM Gutiérrez, C Diaz, A Alape - Scientific reports, 2021 - nature.com
In the current global emergency due to SARS-CoV-2 outbreak, passive immunotherapy
emerges as a promising treatment for COVID-19. Among animal-derived products, equine …

Snake Venomics of the Lancehead Pitviper Bothrops asper: Geographic, Individual, and Ontogenetic Variations

A Alape-Girón, L Sanz, J Escolano… - Journal of proteome …, 2008 - ACS Publications
We report the comparative proteomic characterization of the venoms of adult and newborn
specimens of the lancehead pitviper Bothrops asper from two geographically isolated …

Snake Venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus Complex Points to Neurotoxicity as an Adaptive Paedomorphic …

…, Y Angulo, B Lomonte, A Alape-Girón… - Journal of proteome …, 2010 - ACS Publications
We report a comparative venomic and antivenomic characterization of the venoms of
newborn and adult specimens of the Central American rattlesnake, Crotalus simus, and of the …

Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming

JM Gutiérrez, B Lomonte, G León, A Alape-Giron… - Journal of …, 2009 - Elsevier
Snakebite envenoming represents a neglected tropical disease that has a heavy public
health impact, particularly in Asia, Africa and Latin America. A global initiative, aimed at …

Bacterial sphingomyelinases and phospholipases as virulence factors

…, C Naylor, A Alape-Girón… - Microbiology and …, 2016 - Am Soc Microbiol
Bacterial sphingomyelinases and phospholipases are a heterogeneous group of esterases
which are usually surface associated or secreted by a wide variety of Gram-positive and …

[PDF][PDF] Comparative study on the ability of IgG and F (ab') 2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (coral snake) venom.

G León, B Stiles, A Alape, G Rojas… - The American journal of …, 1999 - academia.edu
A comparative study was performed on the ability of IgG and F (ab) 2 antivenoms to neutralize
lethal and myotoxic activities of Micrurus nigrocinctus venom. Both antivenoms were …

Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue‐damaging activities

…, RH Valente, A Rucavado, A Alape‐Girón… - Protein …, 2003 - Wiley Online Library
BaP1 is a 22.7‐kD P‐I‐type zinc‐dependent metalloproteinase isolated from the venom of
the snake Bothrops asper, a medically relevant species in Central America. This enzyme …

Venoms of Micrurus coral snakes: Evolutionary trends in compositional patterns emerging from proteomic analyses

…, L Sanz, C Corrêa-Netto, V Núñez, A Alape-Girón… - Toxicon, 2016 - Elsevier
The application of proteomic tools to the study of snake venoms has led to an impressive
growth in the knowledge about their composition (venomics), immunogenicity (antivenomics), …

Venomic and Antivenomic Analyses of the Central American Coral Snake, Micrurus nigrocinctus (Elapidae)

J Fernández, A Alape-Girón, Y Angulo… - Journal of proteome …, 2011 - ACS Publications
The proteome of the venom of Micrurus nigrocinctus (Central American coral snake) was
analyzed by a “venomics” approach. Nearly 50 venom peaks were resolved by RP-HPLC, …