According to current models, once the cell has reached terminal differentiation, the enhancer
repertoire is completely established and maintained by cooperatively acting lineage-…

Histone deacetylases (HDACs) regulate inflammatory gene expression, as indicated by the
potent antiinflammatory activity of pan-HDAC inhibitors. However, the specific contribution of …

PURPOSE Recurrently mutated genes and chromosomal abnormalities have been identified
in myelodysplastic syndromes (MDS). We aim to integrate these genomic features into …

Background: Inflammation is a key component of cardiac disease, with macrophages and T
lymphocytes mediating essential roles in the progression to heart failure. Nonetheless, little …

Early prenatal inflammatory conditions are thought to be a risk factor for different
neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy causes …

Tumor-associated macrophages (TAMs) are correlated with the progression of prostatic
adenocarcinoma (PCa). The mechanistic basis of this correlation and therapeutic strategies to …

Fibro-adipogenic progenitors (FAPs) are important components of the skeletal muscle
regenerative environment. Whether FAPs support muscle regeneration or promote fibro-…

Although the pathological significance of tumor-associated macrophage (TAM) heterogeneity
is still poorly understood, TAM reprogramming is viewed as a promising anticancer therapy…

Background & Aims The landscape and function of the immune infiltrate of intrahepatic
cholangiocarcinoma (iCCA), a rare, yet aggressive tumor of the biliary tract, remains poorly …

The transcription factor (TF) interferon regulatory factor 8 (IRF8) controls both developmental
and inflammatory stimulus-inducible genes in macrophages, but the mechanisms …