User profiles for Alec S.T. Smith
 | Alec ST SmithUniversity of Washington, Department of Physiology and Biophysics Verified email at uw.edu Cited by 2798 |
Biomimetic 3D tissue models for advanced high-throughput drug screening
Most current drug screening assays used to identify new drug candidates are 2D cell-based
systems, even though such in vitro assays do not adequately re-create the in vivo complexity …
systems, even though such in vitro assays do not adequately re-create the in vivo complexity …
How multi-organ microdevices can help foster drug development
Multi-organ microdevices can mimic tissue–tissue interactions that occur as a result of metabolite
travel from one tissue to other tissues in vitro. These systems are capable of simulating …
travel from one tissue to other tissues in vitro. These systems are capable of simulating …
Human iPSC-derived cardiomyocytes and tissue engineering strategies for disease modeling and drug screening
AST Smith, J Macadangdang, W Leung… - Biotechnology …, 2017 - Elsevier
Improved methodologies for modeling cardiac disease phenotypes and accurately screening
the efficacy and toxicity of potential therapeutic compounds are actively being sought to …
the efficacy and toxicity of potential therapeutic compounds are actively being sought to …
[HTML][HTML] Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs
We report on a functional human model to evaluate multi-organ toxicity in a 4-organ system
under continuous flow conditions in a serum-free defined medium utilizing a pumpless …
under continuous flow conditions in a serum-free defined medium utilizing a pumpless …
Nanotopography-induced structural anisotropy and sarcomere development in human cardiomyocytes derived from induced pluripotent stem cells
Understanding the phenotypic development of human induced pluripotent stem cell-derived
cardiomyocytes (hiPSC-CMs) is a prerequisite to advancing regenerative cardiac therapy, …
cardiomyocytes (hiPSC-CMs) is a prerequisite to advancing regenerative cardiac therapy, …
Tunable electroconductive decellularized extracellular matrix hydrogels for engineering human cardiac microphysiological systems
Cardiomyocytes differentiated from human induced pluripotent stem cells (hiPSCs) offer
tremendous potential when used to engineer human tissues for drug screening and disease …
tremendous potential when used to engineer human tissues for drug screening and disease …
Micro-and nano-patterned conductive graphene–PEG hybrid scaffolds for cardiac tissue engineering
A lack of electrical conductivity and structural organization in currently available biomaterial
scaffolds limits their utility for generating physiologically representative models of functional …
scaffolds limits their utility for generating physiologically representative models of functional …
In vitro differentiation of functional human skeletal myotubes in a defined system
In vitro human skeletal muscle systems are valuable tools for the study of human muscular
development, disease and treatment. However, published in vitro human muscle systems …
development, disease and treatment. However, published in vitro human muscle systems …
[PDF][PDF] A more open approach is needed to develop cell-based fish technology: it starts with zebrafish
The global demand for fish is rising and projected to increase for years to come. However,
there is uncertainty whether this increased demand can be met by the conventional …
there is uncertainty whether this increased demand can be met by the conventional …
Nanopatterned human iPSC-based model of a dystrophin-null cardiomyopathic phenotype
J Macadangdang, X Guan, AST Smith, R Lucero… - Cellular and molecular …, 2015 - Springer
Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) offer unprecedented
opportunities to study inherited heart conditions in vitro, but are phenotypically immature…
opportunities to study inherited heart conditions in vitro, but are phenotypically immature…