User profiles for Aled Parry
Aled John ParryAltos Labs Verified email at altoslabs.com Cited by 1954 |
G-quadruplex structures mark human regulatory chromatin
G-quadruplex (G4) structural motifs have been linked to transcription 1, 2, replication 3 and
genome instability 4, 5 and are implicated in cancer and other diseases 6, 7, 8. However, it is …
genome instability 4, 5 and are implicated in cancer and other diseases 6, 7, 8. However, it is …
NOTCH1 mediates a switch between two distinct secretomes during senescence
Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse
secretome, which provides complex functionality for senescent cells within the tissue …
secretome, which provides complex functionality for senescent cells within the tissue …
Active turnover of DNA methylation during cell fate decisions
DNA methylation is a key layer of epigenetic regulation. The deposition of methylation marks
relies on the catalytic activity of DNA methyltransferases (DNMTs), and their active removal …
relies on the catalytic activity of DNA methyltransferases (DNMTs), and their active removal …
Multi-omic rejuvenation of human cells by maturation phase transient reprogramming
Ageing is the gradual decline in organismal fitness that occurs over time leading to tissue
dysfunction and disease. At the cellular level, ageing is associated with reduced function, …
dysfunction and disease. At the cellular level, ageing is associated with reduced function, …
IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype
Interleukin‐1 alpha (IL‐1α) is a powerful cytokine that modulates immunity, and requires
canonical cleavage by calpain for full activity. Mature IL‐1α is produced after inflammasome …
canonical cleavage by calpain for full activity. Mature IL‐1α is produced after inflammasome …
[HTML][HTML] Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains
The architectural protein CTCF is a mediator of chromatin conformation, but how CTCF
binding to DNA is orchestrated to maintain long-range gene expression is poorly understood. …
binding to DNA is orchestrated to maintain long-range gene expression is poorly understood. …
Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment
MA Eckersley-Maslin, A Parry, M Blotenburg… - Nature structural & …, 2020 - nature.com
How the epigenetic landscape is established in development is still being elucidated. Here,
we uncover developmental pluripotency associated 2 and 4 (DPPA2/4) as epigenetic …
we uncover developmental pluripotency associated 2 and 4 (DPPA2/4) as epigenetic …
[HTML][HTML] NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
Senescent cells interact with the surrounding microenvironment achieving diverse functional
outcomes. We have recently identified that NOTCH1 can drive ‘lateral induction’ of a unique …
outcomes. We have recently identified that NOTCH1 can drive ‘lateral induction’ of a unique …
Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington's disease
…, A Golbano, K Crespí‐Vázquez, A Parry… - EMBO Molecular …, 2021 - embopress.org
Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence showing
that increased lamin B1 levels contribute to the pathophysiology of Huntington’s disease (…
that increased lamin B1 levels contribute to the pathophysiology of Huntington’s disease (…
[HTML][HTML] Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
I Olan, AJ Parry, S Schoenfelder, M Narita, Y Ito… - Nature …, 2020 - nature.com
Senescence is a state of stable proliferative arrest, generally accompanied by the
senescence-associated secretory phenotype, which modulates tissue homeostasis. Enhancer-…
senescence-associated secretory phenotype, which modulates tissue homeostasis. Enhancer-…