Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529)
harboring up to 36 mutations in spike protein, the target of neutralizing antibodies…

Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However,
ongoing surveillance has revealed the emergence of variants harboring mutations in …

SARS-CoV-2 variants of concern (VOC) have arisen independently at multiple locations 1 ,
2 and may reduce the efficacy of current vaccines that target the spike glycoprotein of SARS-…

Coronavirus disease 2019 (COVID-19) exhibits variable symptom severity ranging from
asymptomatic to life-threatening, yet the relationship between severity and the humoral immune …

The SARS-CoV-2 Omicron variant (B.1.1.529) contains mutations that mediate escape from
antibody responses, although the extent to which these substitutions in spike and non-spike …

SARS-CoV-2 enters cells using its Spike protein, which is also the main target of
neutralizing antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated …

Despite tremendous efforts, development of an effective vaccine against human immunodeficiency
virus (HIV) has proved an elusive goal. Recently, however, numerous antibodies …

Latency and ongoing replication 1 have both been proposed to explain the drug-insensitive
human immunodeficiency virus (HIV) reservoir maintained during antiretroviral therapy. …

The hematopoietic stem cell (HSC) is a unique cell type found in bone marrow, which has
the capacity for both self-renewal and differentiation into all blood lineages. The identification …

The production of blood cells depends on a rare hematopoietic stem-cell (HSC) population,
but the molecular mechanisms underlying HSC biology remain incompletely understood. …