User profiles for Alejandro B. Balazs

Alejandro Balazs

Assistant Professor at the Ragon Institute of MGH, MIT and Harvard
Verified email at mgh.harvard.edu
Cited by 11308

[PDF][PDF] mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant

…, AG Schmidt, AJ Iafrate, V Naranbhai, AB Balazs - Cell, 2022 - cell.com
Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529)
harboring up to 36 mutations in spike protein, the target of neutralizing antibodies…

[HTML][HTML] Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

…, AG Schmidt, AJ Iafrate, V Naranbhai, AB Balazs - Cell, 2021 - cell.com
Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However,
ongoing surveillance has revealed the emergence of variants harboring mutations in …

[HTML][HTML] Escape of SARS-CoV-2 501Y. V2 from neutralization by convalescent plasma

…, F Karim, Y Ganga, K Khan, M Bernstein, AB Balazs… - Nature, 2021 - nature.com
SARS-CoV-2 variants of concern (VOC) have arisen independently at multiple locations 1 ,
2 and may reduce the efficacy of current vaccines that target the spike glycoprotein of SARS-…

[PDF][PDF] COVID-19-neutralizing antibodies predict disease severity and survival

…, D Lingwood, AG Schmidt, AJ Iafrate, AB Balazs - Cell, 2021 - cell.com
Coronavirus disease 2019 (COVID-19) exhibits variable symptom severity ranging from
asymptomatic to life-threatening, yet the relationship between severity and the humoral immune …

[PDF][PDF] T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals

…, EC Lam, M Carrington, WF Garcia-Beltran, AB Balazs… - Cell, 2022 - cell.com
The SARS-CoV-2 Omicron variant (B.1.1.529) contains mutations that mediate escape from
antibody responses, although the extent to which these substitutions in spike and non-spike …

[HTML][HTML] Protocol and reagents for pseudotyping lentiviral particles with SARS-CoV-2 spike protein for neutralization assays

…, D Veesler, M Murphy, D Pettie, NP King, AB Balazs… - Viruses, 2020 - mdpi.com
SARS-CoV-2 enters cells using its Spike protein, which is also the main target of
neutralizing antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated …

Antibody-based protection against HIV infection by vectored immunoprophylaxis

AB Balazs, J Chen, CM Hong, DS Rao, L Yang… - Nature, 2012 - nature.com
Despite tremendous efforts, development of an effective vaccine against human immunodeficiency
virus (HIV) has proved an elusive goal. Recently, however, numerous antibodies …

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

A Sigal, JT Kim, AB Balazs, E Dekel, A Mayo, R Milo… - Nature, 2011 - nature.com
Latency and ongoing replication 1 have both been proposed to explain the drug-insensitive
human immunodeficiency virus (HIV) reservoir maintained during antiretroviral therapy. …

Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow

AB Balazs, AJ Fabian, CT Esmon, RC Mulligan - Blood, 2006 - ashpublications.org
The hematopoietic stem cell (HSC) is a unique cell type found in bone marrow, which has
the capacity for both self-renewal and differentiation into all blood lineages. The identification …

MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output

…, DS Rao, WSJ Gibson, AB Balazs… - Proceedings of the …, 2010 - National Acad Sciences
The production of blood cells depends on a rare hematopoietic stem-cell (HSC) population,
but the molecular mechanisms underlying HSC biology remain incompletely understood. …