The functions of the Snail family of zinc-finger transcription factors are essential during embryonic
development. One of their best-known functions is to induce epithelial to mesenchymal …

The epithelial-mesenchymal transition (EMT) is required in the embryo for the formation of
tissues for which cells originate far from their final destination. Carcinoma cells hijack this …

Neural crest progenitor cells are the main contributors to craniofacial cartilage and
connective tissue of the vertebrate head. These progenitor cells also give rise to the pigment, …

Protein transport from endoplasmic reticulum (ER) to Golgi is primarily conducted by coated
vesicular carriers such as COPII. Here, we describe zebrafish bulldog mutations that disrupt …

Volume-regulated anion channels (VRACs) play an important role in controlling cell volume
by opening upon cell swelling. Recent work has shown that heteromers of LRRC8A with …

Tfap2a is a transcriptional activator expressed in many different cell types, including neurons,
neural crest derivatives and epidermis. We show that mutations at the zebrafish locus …

The Snail transcription factors have crucial roles in metazoan development and disease. A
phylogenetic analysis from placozoans to humans confirms that, along with the Scratch genes…

The Snail genes are implicated in processes that involve cell movement,both during
embryonic development and tumour progression. In teleosts, the vertebrate Snail1 gene is …

Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a leukodystrophy
characterized by myelin vacuolization and caused by mutations in MLC1 or GLIALCAM. …

Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare type of
leukodystrophy caused by mutations in either MLC1 or GLIALCAM. GlialCAM is necessary for the …