User profiles for Alejandro Barrera

Alejandro Barrera

- Verified email at duke.edu - Cited by 2378

Alejandro Barrera

- Verified email at med.uchile.cl - Cited by 665

Alejandro Barrera del Pozo

- Verified email at pa.uc3m.es - Cited by 234

[HTML][HTML] Reoperaciones precoces en cirugía colorrectal: Análisis uni y multivariado de factores de riesgo

G Bannura, MA Cumsille, A Barrera… - Revista chilena de …, 2007 - SciELO Chile
BANNURA C, GUILLERMO et al. Reoperaciones precoces en cirugía colorrectal: Análisis
uni y multivariado de factores de riesgo. Rev Chil Cir [online]. 2007, vol. 59, n. 4, pp. 281-286. …

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

…, TJ Hofmann, SL Maude, P Raman, A Barrera… - Cancer discovery, 2015 - AACR
The CD19 antigen, expressed on most B-cell acute lymphoblastic leukemias (B-ALL), can
be targeted with chimeric antigen receptor–armed T cells (CART-19), but relapses with …

A new view of transcriptome complexity and regulation through the lens of local splicing variations

J Vaquero-Garcia, A Barrera, MR Gazzara… - elife, 2016 - elifesciences.org
10.7554/eLife.11752.001 Alternative splicing (AS) can critically affect gene function and
disease, yet mapping splicing variations remains a challenge. Here, we propose a new …

[HTML][HTML] Factores asociados a la dehiscencia clínica de una anastomosis intestinal grapada: análisis multivariado de 610 pacientes consecutivos

G Bannura, MA Cumsille, A Barrera… - Revista chilena de …, 2006 - SciELO Chile
BANNURA C, GUILLERMO et al. Factores asociados a la dehiscencia clínica de una anastomosis
intestinal grapada: análisis multivariado de 610 pacientes consecutivos. Rev Chil Cir […

Transgenic mice for in vivo epigenome editing with CRISPR-based systems

…, E Rodriguez, KR Tonn-Eisinger, A Barrera… - Nature …, 2021 - nature.com
CRISPR-Cas9 technologies have dramatically increased the ease of targeting DNA sequences
in the genomes of living systems. The fusion of chromatin-modifying domains to nuclease…

Predictive factors of stenosis after stapled colorectal anastomosis: prospective analysis of 179 consecutive patients

GC Bannura, MAG Cumsille, AE Barrera… - World journal of …, 2004 - Springer
The incidence, risk factors, and clinical relevance of stenosis of stapled colorectal anastomosis
(CRA) were studied prospectively. Anastomotic stricture was defined as the inability of …

[HTML][HTML] Transcriptional and epigenetic regulators of human CD8+ T cell function identified through orthogonal CRISPR screens

SR McCutcheon, AM Swartz, MC Brown, A Barrera… - Nature Genetics, 2023 - nature.com
Clinical response to adoptive T cell therapies is associated with the transcriptional and
epigenetic state of the cell product. Thus, discovery of regulators of T cell gene networks and their …

Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding

IC McDowell, A Barrera, AM D'Ippolito… - Genome …, 2018 - genome.cshlp.org
Glucocorticoids are potent steroid hormones that regulate immunity and metabolism by
activating the transcription factor (TF) activity of glucocorticoid receptor (GR). Previous models …

Birdnet+: End-to-end 3d object detection in lidar bird's eye view

A Barrera, C Guindel, J Beltrán… - 2020 IEEE 23rd …, 2020 - ieeexplore.ieee.org
On-board 3D object detection in autonomous vehicles often relies on geometry information
captured by LiDAR devices. Albeit image features are typically preferred for detection, …

[PDF][PDF] Pre-established chromatin interactions mediate the genomic response to glucocorticoids

AM D'Ippolito, IC McDowell, A Barrera, LK Hong… - Cell systems, 2018 - cell.com
The glucocorticoid receptor (GR) is a hormone-inducible transcription factor involved in
metabolic and anti-inflammatory gene expression responses. To investigate what controls …