Under normal conditions, there is a paucity of neutrophils within the intestinal mucosa; however,
these innate immune cells rapidly infiltrate the mucosa in response to infection and are …

Gastrointestinal infections cause significant morbidity and mortality worldwide. The complexity
of human biology and limited insights into host-specific infection mechanisms are key …

Background Functional constipation is defined as chronic constipation with no identifiable
underlying cause. It is a significant cause of morbidity in children, accounting for up to 25% of …

Objective: Enteric bacterial pathogens cause diarrheal disease and mortality at significant
rates throughout the world, particularly in children younger than 5 years. Our ability to combat …

Throughout the course of infection, many pathogens encounter bactericidal conditions that
threaten the viability of the bacteria and impede the establishment of infection. Bile is one of …

In children, functional gastrointestinal disorders (FGIDs) are common at all ages. Consumption
of certain foods, particularly gluten, is frequently associated with the development and …

Functional gastrointestinal disorders (FGIDs) and functional abdominal pain disorders (FAPDs)
are common in pediatric patients. The prevalence of FGIDs using the Rome IV criteria …

The Shigella species are Gram-negative, facultative intracellular pathogens that invade the
colonic epithelium and cause significant diarrheal disease. Despite extensive research on …

Background One of the criteria for functional constipation (FC) in Rome IV criteria is the
presence of hard or painful bowel movements. In adults and children, the Rome IV criteria …

Research specific to pediatrics is needed, particularly in post-infectious disorders of the gut-brain
interaction (PI-DGBIs) and long COVID-19. Data extrapolated from adult trials may not …