User profiles for Aleksejs Sazonovs
 | Aleksejs SazonovsWellcome Trust Sanger Institute Verified email at sanger.ac.uk Cited by 837 |
[HTML][HTML] HLA-DQA1* 05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's disease
Background & Aims Anti–tumor necrosis factor (anti-TNF) therapies are the most widely
used biologic drugs for treating immune-mediated diseases, but repeated administration can …
used biologic drugs for treating immune-mediated diseases, but repeated administration can …
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility
Genome-wide association studies (GWASs) have identified hundreds of loci associated with
Crohn’s disease (CD). However, as with all complex diseases, robust identification of the …
Crohn’s disease (CD). However, as with all complex diseases, robust identification of the …
NetworKit: A tool suite for large-scale complex network analysis
CL Staudt, A Sazonovs, H Meyerhenke - Network Science, 2016 - cambridge.org
We introduce NetworKit, an open-source software package for analyzing the structure of large
complex networks. Appropriate algorithmic solutions are required to handle increasingly …
complex networks. Appropriate algorithmic solutions are required to handle increasingly …
[PDF][PDF] Networkit: An interactive tool suite for high-performance network analysis
C Staudt, A Sazonovs, H Meyerhenke - arXiv preprint arXiv …, 2014 - parco.iti.kit.edu
We introduce NetworKit, an open-source software package for high-performance analysis of
large complex networks. Complex networks are equally attractive and challenging targets …
large complex networks. Complex networks are equally attractive and challenging targets …
Common and rare variant prediction and penetrance of IBD in a large, multi-ethnic, health system-based biobank cohort
Background and Aims Polygenic risk scores (PRS) may soon be used to predict inflammatory
bowel disease (IBD) risk in prevention efforts. We leveraged exome-sequence and single …
bowel disease (IBD) risk in prevention efforts. We leveraged exome-sequence and single …
Sequencing of over 100,000 individuals identifies multiple genes and rare variants associated with Crohns disease susceptibility
Genome-wide association studies (GWAS) have identified hundreds of loci associated with
Crohns disease (CD), however, as with all complex diseases, deriving pathogenic …
Crohns disease (CD), however, as with all complex diseases, deriving pathogenic …
Underpowered PANTS: a response to the conclusions of “extended analysis identifies drug-specific association of two distinct HLA class II haplotypes for development …
In our original study, we decided a priori to maximize power to detect genetic variants
associated with immunogenicity to anti-TNFs by including patients treated with either drug in the …
associated with immunogenicity to anti-TNFs by including patients treated with either drug in the …
HLA-DQA1* 05 is associated with the development of antibodies to anti-TNF therapy
Background Anti-tumour necrosis factor (anti-TNF) therapies are the most widely used biologic
therapies for treating immune-mediated diseases. Their efficacy is significantly reduced …
therapies for treating immune-mediated diseases. Their efficacy is significantly reduced …
Prevalence of NUDT15 Genetic Variants and Incidence of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis
…, GJ Walker, A Sazonovs… - Journal of Crohn's …, 2023 - academic.oup.com
Background and Aims Nudix hydrolase 15 [NUDT15] genetic variants confer an increased
risk of thiopurine-induced leukopenia [TIL]; however, their global prevalence in inflammatory …
risk of thiopurine-induced leukopenia [TIL]; however, their global prevalence in inflammatory …
OTU-002 HLA-DQA1 contributes to the development of antibodies to anti-TNF therapy in Crohn's disease
Background Immunogenicity to anti-TNF therapy is a major cause of loss of response, treatment
discontinuation and hypersensitivity reactions and currently cannot be predicted prior to …
discontinuation and hypersensitivity reactions and currently cannot be predicted prior to …