Esophageal squamous cell carcinoma (ESCC) is among the most deadly forms of human
malignancy characterized by late stage diagnosis, metastasis, therapy resistance and frequent …

Although morphologic progression coupled with expression of specific molecular markers
has been characterized along the esophageal squamous differentiation gradient, the …

Esophageal cancer is among the most aggressive forms of human malignancy with five-year
survival rates of <20%. Autophagy is an evolutionarily conserved catabolic process that …

The intestinal epithelium exhibits a rapid and efficient regenerative response to injury.
Emerging evidence supports a model where plasticity of differentiated cells, particularly those in …

Subepithelial fibrosis occurs in a subset of eosinophilic esophagitis (EoE) patients and is
associated with esophageal stricture. While mechanisms driving EoE fibrosis remain …

Background & Aims Autophagy plays roles in esophageal pathologies both benign and
malignant. Here, we aim to define the role of autophagy in esophageal epithelial homeostasis. …

In pancreatic ductal adenocarcinoma (PDAC), the fibroblastic stroma constitutes most of the
tumor mass and is remarkably devoid of functional blood vessels. This raises an unresolved …

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive forms of human
malignancy, often displaying limited therapeutic response. Here, we examine the non-…

Under homeostatic conditions, esophageal epithelium displays a proliferation/differentiation
gradient that is generated as proliferative basal cells give rise to suprabasal cells then …

Although morphologic progression coupled with expression of specific molecular markers
has been characterized along the esophageal squamous differentiation gradient, the …