Leukotriene B 4 (LTB 4 ) is a lipid mediator derived from arachidonic acid (AA) by the sequential
action of 5-lipoxygenase (5-LOX), 5-lipoxygenase-activating protein (FLAP) and LTA 4 …

Eight mutants of the DhaA haloalkane dehalogenase carrying mutations at the residues lining
two tunnels, previously observed by protein X-ray crystallography, were constructed and …

Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and
urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining …

Assembly of extracellular filaments and matrices mediating fundamental biological processes
such as morphogenesis, hearing, fertilization, and antibacterial defense is driven by a …

Leukotriene (LT) A 4 hydrolase/aminopeptidase (LTA4H) is a bifunctional zinc metalloenzyme
that catalyzes the committed step in the formation of the proinflammatory mediator LTB 4 . …

Human leukotriene (LT) A 4 hydrolase/aminopeptidase (LTA 4 H) is a bifunctional enzyme
that converts the highly unstable epoxide intermediate LTA 4 into LTB 4 , a potent leukocyte …

Following the fertilization of an egg by a single sperm, the egg coat or zona pellucida (ZP)
hardens and polyspermy is irreversibly blocked. These events are associated with the …

Haloalkane dehalogenases catalyze the hydrolytic cleavage of carbon–halogen bonds,
which is a key step in the aerobic mineralization of many environmental pollutants. One …

Pathogens often receive antibiotic resistance genes through horizontal gene transfer from
bacteria that produce natural antibiotics. ErmE is a methyltransferase (MTase) from …

The haloalkane dehalogenase DhaA from Rhodococcus rhodochrous NCIMB 13064 is a
bacterial enzyme that shows catalytic activity for the hydrolytic degradation of the highly toxic …