User profiles for Alessandra Breschi

Alessandra Breschi

Stanford University
Verified email at stanford.edu
Cited by 5358

[HTML][HTML] A comparative encyclopedia of DNA elements in the mouse genome

F Yue, Y Cheng, A Breschi, J Vierstra, W Wu, T Ryba… - Nature, 2014 - nature.com
The laboratory mouse shares the majority of its protein-coding genes with humans, making
it the premier model organism in biomedical research, yet the two mammals differ in …

Comparison of the transcriptional landscapes between human and mouse tissues

…, Y Lin, JR Nery, MA Urich, A Breschi… - Proceedings of the …, 2014 - National Acad Sciences
Although the similarities between humans and mice are typically highlighted, morphologically
and genetically, there are many differences. To better understand these two species on a …

[HTML][HTML] Glucotypes reveal new patterns of glucose dysregulation

H Hall, D Perelman, A Breschi, P Limcaoco… - PLoS …, 2018 - journals.plos.org
Diabetes is an increasing problem worldwide; almost 30 million people, nearly 10% of the
population, in the United States are diagnosed with diabetes. Another 84 million are …

Transcriptional diversity during lineage commitment of human blood progenitors

…, WJ Astle, A Attwood, T Bariana, B De Bono, A Breschi… - Science, 2014 - science.org
Introduction Blood production in humans culminates in the daily release of around 10 11
cells into the circulation, mainly platelets and red blood cells. All blood cells originate from a …

[HTML][HTML] The effects of death and post-mortem cold ischemia on human tissue transcriptomes

…, J Carbonell-Caballero, R Nurtdinov, A Breschi… - Nature …, 2018 - nature.com
Post-mortem tissues samples are a key resource for investigating patterns of gene expression.
However, the processes triggered by death and the post-mortem interval (PMI) can …

Comparative transcriptomics in human and mouse

A Breschi, TR Gingeras, R Guigó - Nature Reviews Genetics, 2017 - nature.com
Cross-species comparisons of genomes, transcriptomes and gene regulation are now
feasible at unprecedented resolution and throughput, enabling the comparison of human and …

[HTML][HTML] ggsashimi: Sashimi plot revised for browser-and annotation-independent splicing visualization

…, E Palumbo, R Guigó, A Breschi - PLoS computational …, 2018 - journals.plos.org
We present ggsashimi, a command-line tool for the visualization of splicing events across
multiple samples. Given a specified genomic region, ggsashimi creates sashimi plots for …

[HTML][HTML] Gene-specific patterns of expression variation across organs and species

A Breschi, S Djebali, J Gillis, DD Pervouchine, A Dobin… - Genome biology, 2016 - Springer
Background A comparison of transcriptional profiles derived from different tissues in a given
species or among different species assumes that commonalities reflect evolutionarily …

[HTML][HTML] Enhanced transcriptome maps from multiple mouse tissues reveal evolutionary constraint in gene expression

DD Pervouchine, S Djebali, A Breschi, CA Davis… - Nature …, 2015 - nature.com
Mice have been a long-standing model for human biology and disease. Here we characterize,
by RNA sequencing, the transcriptional profiles of a large and heterogeneous collection …

A limited set of transcriptional programs define major cell types

A Breschi, M Muñoz-Aguirre, V Wucher… - Genome …, 2020 - genome.cshlp.org
We have produced RNA sequencing data for 53 primary cells from different locations in the
human body. The clustering of these primary cells reveals that most cells in the human body …