Distinct classes of neurons are generated at defined positions in the ventral neural tube in
response to a gradient of Sonic Hedgehog (Shh) activity. A set of homeodomain transcription …

Cajal-Retzius cells are critical in cortical lamination, but very little is known about their origin
and development. The homeodomain transcription factor Dbx1 is expressed in restricted …

The generation of a precise number of neural cells and the determination of their laminar fate
are tightly controlled processes during development of the cerebral cortex. Using genetic …

Most developing thymocytes undergo apoptosis because they cannot interact productively
with molecules encoded by the major histocompatibility complex. Here, we show that mice …

The sequential stepping of left and right limbs is a fundamental motor behavior that underlies
walking movements. This relatively simple locomotor behavior is generated by the rhythmic …

Sonic hedgehog (Shh) is thought to control the generation of motor neurons and interneurons
in the ventral CNS. We show here that a Shh-independent pathway of interneuron …

Dorsal horn neurons in the spinal cord integrate and relay sensory information. Here, we
show that the expression of the homeobox gene Lbx1 distinguishes two major neuronal …

All forms of locomotion are repetitive motor activities that require coordinated bilateral activation
of muscles. The executive elements of locomotor control are networks of spinal neurons …

GABA-containing (GABAergic) interneurons play an important role in the function of the
cerebral cortex. Through mostly inhibitory mechanisms, interneurons control hyperexcitability …

Abstract Specification of neuronal fate in the vertebrate central nervous system depends on
the profile of transcription factor expression by neural progenitor cells, but the precise roles …