Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T
cell rich tumors fail to respond to immune checkpoint blockade (ICB). We leveraged a …

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an …

Monocyte exposure to LPS induces a transient state in which these cells are refractory to
further endotoxin stimulation. This phenomenon, termed endotoxin tolerance (ET), is …

Background Whether young adults who are infected with SARS-CoV-2 are at risk of subsequent
infection is uncertain. We investigated the risk of subsequent SARS-CoV-2 infection …

Triggering receptors expressed on myeloid cell (TREM) proteins are a family of cell surface
receptors that participate in diverse cellular processes such as inflammation, coagulation, …

Background The efficacy of public health measures to control the transmission of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has not been well studied in young …

Congenital Zika syndrome (CZS) causes early brain development impairment by affecting
neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins …

During persistent antigen stimulation, such as in chronic infections and cancer, CD8 T cells
differentiate into a hypofunctional programmed death protein 1–positive (PD-1 + ) exhausted …

Background The pathogenesis of severe dengue disease involves immune components as
biomarkers. The mechanism by which some dengue virus (DENV)–infected individuals …

Cystic Fibrosis (CF) is an inherited pleiotropic disease that results from abnormalities in the
gene that codes for the chloride channel, Cystic Fibrosis Transmembrane Conductance …