In all vertebrate species studied thus far, the adult central nervous system harbors neural
stem cells that sustain constitutive neurogenesis, as well as latent neural progenitors that can …

Maintaining the homeostasis of germinal zones in adult organs is a fundamental but
mechanistically poorly understood process. In particular, what controls stem cell activation remains …

Ventral midline Sonic Hedgehog (Shh) signalling is crucial for growth and patterning of the
embryonic forebrain. Here, we report how enhanced Shh midline signalling affects the …

Few adult neural stem cells have been characterized in vertebrates. Although teleosts
continually generate new neurons in many regions of the brain after embryogenesis, only two …

Neural stem cells (NSCs) in the adult vertebrate brain are found in a quiescent state and
can preserve long-lasting progenitor potential (stemness). Whether and how these two …

We review the anatomical and functional features of circumventricular organs in vertebrates
and their homologous neurohemal organs in invertebrates. Focusing on cyclostomes (…

The teleost brain has the remarkable ability to generate new neurons and to repair injuries
during adult life stages. Maintaining life-long neurogenesis requires careful management of …

Live imaging of adult neural stem cells (aNSCs) in vivo is a technical challenge in the
vertebrate brain. Here, we achieve long-term imaging of the adult zebrafish telencephalic …

All subdivisions of the adult zebrafish brain maintain niches of constitutive neurogenesis,
sustained by quiescent and multipotent progenitor populations. In the telencephalon, the latter …

The sighted surface-dwelling (surface fish, SF) and the blind cave-living (cavefish, CF) forms
of Astyanax mexicanus offer a unique opportunity to study the evolutionary changes in …