The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of
genomic loci 1 . Recent work suggested that rather than up- and downregulating selected …

The acetyl-transferase Tip60 might influence tumorigenesis in multiple ways 1 . First, Tip60
is a co-regulator of transcription factors that either promote or suppress tumorigenesis, such …

Activated oncogenes induce compensatory tumour-suppressive responses, such as cellular
senescence or apoptosis, but the signals determining the main outcome remain to be fully …

We report here the identification of a new shared human melanoma antigen recognized by a
human leukocyte antigen (HLA)-A*68011–restricted cytotoxic T lymphocyte clone (CTL 128)…

Mammalian cells must integrate environmental cues to determine coherent physiological
responses. The transcription factors Myc and YAP–TEAD act downstream from mitogenic …

Tumors driven by activation of the transcription factor MYC generally show oncogene
addiction. However, the gene expression programs that depend upon sustained MYC activity …

MYC is a key oncogenic driver in multiple tumor types, but concomitantly endows cancer
cells with a series of vulnerabilities that provide opportunities for targeted pharmacological …

Upon activation, lymphocytes exit quiescence and undergo substantial increases in cell size,
accompanied by activation of energy‐producing and anabolic pathways, widespread …

Overexpression of the MYC transcription factor causes its widespread interaction with
regulatory elements in the genome but leads to the up- and down-regulation of discrete sets of …

Primary mouse embryonic fibroblasts (MEFs) are a popular tool for molecular and cell biology
studies. However, when MEFs are grown in vitro under standard tissue culture conditions, …