[HTML][HTML] Neural stem cells traffic functional mitochondria via extracellular vesicles
…, JC Williamson, A Braga, A van den Bosch… - PLoS …, 2021 - journals.plos.org
Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous
system (CNS) diseases. Although the replacement of lost endogenous cells was originally …
system (CNS) diseases. Although the replacement of lost endogenous cells was originally …
Ultrastructural axon–myelin unit alterations in multiple sclerosis correlate with inflammation
AMR van den Bosch, S Hümmert, A Steyer… - Annals of …, 2023 - Wiley Online Library
Objective Changes in the normal‐appearing white matter (NAWM) in multiple sclerosis (MS)
may contribute to disease progression. Here, we systematically quantified ultrastructural …
may contribute to disease progression. Here, we systematically quantified ultrastructural …
Neurofilament light chain levels in multiple sclerosis correlate with lesions containing foamy macrophages and with acute axonal damage
A van den Bosch, N Fransen, M Mason… - Neurology …, 2022 - AAN Enterprises
Background and Objectives To investigate whether white matter lesion activity, acute axonal
damage, and axonal density in MS associate with CSF neurofilament light chain (NfL) levels…
damage, and axonal density in MS associate with CSF neurofilament light chain (NfL) levels…
[HTML][HTML] Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73
…, J Hester, T Ashmore, A Van Den Bosch… - Communications …, 2021 - nature.com
The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in
transplantation and autoimmunity. However, because large cell numbers are needed to …
transplantation and autoimmunity. However, because large cell numbers are needed to …
[HTML][HTML] Resting-state fMRI reveals network disintegration during delirium
SJT van Montfort, E van Dellen, AMR van den Bosch… - NeuroImage: Clinical, 2018 - Elsevier
… Author links open overlay panel Simone JT van Montfort a , Edwin van Dellen b c , Aletta
MR van den Bosch a d , Willem M. Otte e f , Maya JL Schutte b , Soo-Hee Choi g , Tae-Sub …
MR van den Bosch a d , Willem M. Otte e f , Maya JL Schutte b , Soo-Hee Choi g , Tae-Sub …
[HTML][HTML] SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke
…, D Maric, KR Johnson, Y Mou, A Van Den Bosch… - …, 2019 - thelancet.com
Background Neural stem cell (NSC)-based therapies hold great promise for treating diseases
of the central nervous system (CNS). However, several fundamental problems still need to …
of the central nervous system (CNS). However, several fundamental problems still need to …
White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue-resident memory T cells.
…, NL Fransen, AMR van den Bosch… - European journal of …, 2020 - europepmc.org
Brain CD8+ CD69+ tissue-resident memory T (T RM) cells comprise a CD20 dim subset,
which is proportionally larger in CD103-negative T RM cells. In multiple sclerosis (MS) lesions, …
which is proportionally larger in CD103-negative T RM cells. In multiple sclerosis (MS) lesions, …
[HTML][HTML] Profiling of microglia nodules in multiple sclerosis reveals propensity for lesion formation
AMR van den Bosch, M van der Poel… - Nature …, 2024 - nature.com
Microglia nodules (HLA-DR + cell clusters) are associated with brain pathology. In this post-mortem
study, we investigated whether they represent the first stage of multiple sclerosis (MS…
study, we investigated whether they represent the first stage of multiple sclerosis (MS…
Identification of neuropathology-based subgroups in multiple sclerosis using a data-driven approach
A de Boer, AMR van den Bosch, NJ Mekkes, N Fransen… - medRxiv, 2023 - medrxiv.org
Multiple sclerosis (MS) is a heterogeneous disorder with regards to clinical presentation
and pathophysiology. Stratification into biologically distinct subgroups could enhance …
and pathophysiology. Stratification into biologically distinct subgroups could enhance …
Neural stem cells traffic functional mitochondria via extracellular vesicles to correct mitochondrial dysfunction in target cells
…, JC Williamson, A Braga, A van den Bosch… - bioRxiv, 2020 - biorxiv.org
Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous
system (CNS) diseases. Although the replacement of lost endogenous cells was originally …
system (CNS) diseases. Although the replacement of lost endogenous cells was originally …