User profiles for Alex Blakemore

Alexandra IF Blakemore

Professor of Human Genetics, Department of Life Sciences, Brunel University London
Verified email at brunel.ac.uk
Cited by 21756

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

…, S Bergmann, H Biebermann, AIF Blakemore… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

Technologies for global health

…, GZ Yang, H Ashrafian, R Atun, J Barlow, A Blakemore… - The Lancet, 2012 - thelancet.com
Availability of health technology is inversely related to health need. Although health-care
systems in high-income countries make extensive use of technology, people in the world's …

Copy number variation at 1q21. 1 associated with neuroblastoma

…, C Kim, EA Geiger, PW McGrady, AIF Blakemore… - Nature, 2009 - nature.com
Common copy number variations (CNVs) represent a significant source of genetic diversity,
yet their influence on phenotypic variability, including disease susceptibility, remains poorly …

Automated generation and analysis of Markov reward models using stochastic reward nets

G Ciardo, A Blakemore, PF Chimento Jr… - Linear algebra, Markov …, 1993 - Springer
Markov and Markov reward models are widely used for the performance and reliability
analysis of computer and communication systems. Models of real systems often contain …

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

…, H Oksa, JC Chambers, JS Kooner, AIF Blakemore… - Nature …, 2016 - nature.com
High blood pressure is a major risk factor for cardiovascular disease and premature death.
However, there is limited knowledge on specific causal genes and pathways. To better …

British Obesity and Metabolic Surgery Society Guidelines on perioperative and postoperative biochemical monitoring and micronutrient replacement for patients …

…, KK Mahawar, M Sharma, AI Blakemore… - Obesity …, 2020 - Wiley Online Library
Bariatric surgery is recognized as the most clinically and cost‐effective treatment for people
with severe and complex obesity. Many people presenting for surgery have pre‐existing low …

Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat

JK Tarlow, AIF Blakemore, A Lennard, R Solari… - Human genetics, 1993 - Springer
We have investigated the polymorphism in intron 2 of the interleukin-1 receptor antagonist
gene and identified two new alleles of the system. We have shown that the polymorphism is …

Identification of seven loci affecting mean telomere length and their association with disease

…, AL Catapano, MD Tobin, AS Hall, AIF Blakemore… - Nature …, 2013 - nature.com
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

…, B Heude, M Tauber, MI McCarthy, AIF Blakemore… - Nature …, 2009 - nature.com
We analyzed genome-wide association data from 1,380 Europeans with early-onset and
morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers …

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

…, C Lévy-Marchal, F Pattou, D Meyre, AIF Blakemore… - Nature …, 2009 - nature.com
In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we
identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a …