User profiles for Alex Blakemore
Alexandra IF BlakemoreProfessor of Human Genetics, Department of Life Sciences, Brunel University London Verified email at brunel.ac.uk Cited by 21756 |
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
…, S Bergmann, H Biebermann, AIF Blakemore… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
Technologies for global health
Availability of health technology is inversely related to health need. Although health-care
systems in high-income countries make extensive use of technology, people in the world's …
systems in high-income countries make extensive use of technology, people in the world's …
Copy number variation at 1q21. 1 associated with neuroblastoma
…, C Kim, EA Geiger, PW McGrady, AIF Blakemore… - Nature, 2009 - nature.com
Common copy number variations (CNVs) represent a significant source of genetic diversity,
yet their influence on phenotypic variability, including disease susceptibility, remains poorly …
yet their influence on phenotypic variability, including disease susceptibility, remains poorly …
Automated generation and analysis of Markov reward models using stochastic reward nets
G Ciardo, A Blakemore, PF Chimento Jr… - Linear algebra, Markov …, 1993 - Springer
Markov and Markov reward models are widely used for the performance and reliability
analysis of computer and communication systems. Models of real systems often contain …
analysis of computer and communication systems. Models of real systems often contain …
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
…, H Oksa, JC Chambers, JS Kooner, AIF Blakemore… - Nature …, 2016 - nature.com
High blood pressure is a major risk factor for cardiovascular disease and premature death.
However, there is limited knowledge on specific causal genes and pathways. To better …
However, there is limited knowledge on specific causal genes and pathways. To better …
British Obesity and Metabolic Surgery Society Guidelines on perioperative and postoperative biochemical monitoring and micronutrient replacement for patients …
Bariatric surgery is recognized as the most clinically and cost‐effective treatment for people
with severe and complex obesity. Many people presenting for surgery have pre‐existing low …
with severe and complex obesity. Many people presenting for surgery have pre‐existing low …
Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat
JK Tarlow, AIF Blakemore, A Lennard, R Solari… - Human genetics, 1993 - Springer
We have investigated the polymorphism in intron 2 of the interleukin-1 receptor antagonist
gene and identified two new alleles of the system. We have shown that the polymorphism is …
gene and identified two new alleles of the system. We have shown that the polymorphism is …
Identification of seven loci affecting mean telomere length and their association with disease
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …
and several age-associated diseases. We report here a genome-wide meta-analysis of …
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
We analyzed genome-wide association data from 1,380 Europeans with early-onset and
morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers …
morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers …
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we
identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a …
identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a …