Edited by internationally recognized authorities in the field, this expanded and updated new
edition of the bestselling Handbook, containing many new articles, is aimed at the design …

Dengue virus, a member of the family Flaviviridae of positive-strand RNA viruses, has seven
non-structural proteins: NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5. Except for enzymic …

Dengue fever is an important emerging public health concern, with several million viral infections
occurring annually, for which no effective therapy currently exists. The NS3 protein from …

There is an increasing need for comparable and harmonized retention times (t R ) in liquid
chromatography (LC) among different laboratories, to provide supplementary evidence for the …

Arabidopsis det2 mutants are small dark-green dwarfs displaying pleiotropic defects in light-regulated
development during multiple stages of the plant life cycle. The DET2 gene …

Dengue is a mosquito-borne viral hemorrhagic disease that is a major threat to human health
in tropical and subtropical regions. Here we report crystal structures of a peptide covalently …

The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …

Environmental chemicals comprise a major portion of the human exposome, with some
shown to impact the health of susceptible populations, including pregnant women and …

Crystal structure analysis of Flavivirus methyltransferases uncovered a flavivirus-conserved
cavity located next to the binding site for its cofactor, S-adenosyl-methionine (SAM). …

Non-targeted analysis (NTA) encompasses a rapidly evolving set of mass spectrometry
techniques aimed at characterizing the chemical composition of complex samples, identifying …