Type 2 diabetes (T2D) and obesity are complex disorders that constitute major public health
problems. The evidence for familial aggregation of both T2D and obesity is substantial. To …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis
of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult …

Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism,
ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have …

Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are
caused by an interchange between environmental and genetic factors. Recently, a number …

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …

Background Indian Asians, who make up a quarter of the world's population, are at high risk
of developing type 2 diabetes. We investigated whether DNA methylation is associated with …

DNA methylation plays a fundamental role in the regulation of the genome, but the optimal
strategy for analysis of genome-wide DNA methylation data remains to be determined. We …

We carried out a trans-ancestry genome-wide association and replication study of blood
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic
disease risk, we conducted a genome-wide association meta-analysis of body fat …