The microbiome can promote or disrupt human health by influencing both adaptive and
innate immune functions. We tested whether bacteria that normally reside on human skin …

Dietary fibres can exert beneficial anti-inflammatory effects through microbially fermented
short-chain fatty acid metabolites 1 , 2 , although the immunoregulatory roles of most fibre diets …

Obesity is a risk factor for osteoarthritis (OA), the greatest cause of disability in the US. The
impact of obesity on OA is driven by systemic inflammation, and increased systemic …

Background Identification of factors that influence the neonatal gut microbiome is urgently
needed to guide clinical practices that support growth of healthy preterm infants. Here, we …

Candida albicans is an opportunistic fungal organism frequently detected in the oral cavity
of children with severe early childhood caries (S-ECC). Previous studies suggested the …

Background Postnatal development of early life microbiota influences immunity, metabolism,
neurodevelopment, and infant health. Microbiome development occurs at multiple body …

Background: Development of the intestinal microbiome in preterm infants has significant impact
on infant health. Our objective was to determine if duration of antibiotics within the first 10 …

Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections and
hospital visits during infancy and childhood. Although risk factors for RSV infection have been …

Background Current treatment of acute exacerbations of chronic rhinosinusitis (CRS) is driven
by identification of predominant bacteria using culture‐based methods and determination …

Gene editing by homology-directed recombination (HDR) can be used to couple delivery of
a therapeutic gene cassette with targeted genomic modifications to generate engineered …