User profiles for Alex Groisman

Alex Groisman

UCSD, Physics
Verified email at ucsd.edu
Cited by 12188

Microfluidic memory and control devices

A Groisman, M Enzelberger, SR Quake - Science, 2003 - science.org
We demonstrate microscopic fluidic control and memory elements through the use of an
aqueous viscoelastic polymer solution as a working fluid. By exploiting the fluid's non-…

MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast

…, PA Iglesias, K Campbell, Z Hilioti, A Groisman… - Nature, 2007 - nature.com
The mating pathway in Saccharomyces cerevisiae has been the focus of considerable
research effort, yet many quantitative aspects of its regulation still remain unknown. Using an …

A microfluidic chemostat for experiments with bacterial and yeast cells

A Groisman, C Lobo, HJ Cho, JK Campbell… - Nature …, 2005 - nature.com
Bacteria and yeast frequently exist as populations capable of reaching extremely high cell
densities. With conventional culturing techniques, however, cell proliferation and ultimate …

Separation of plasma from whole human blood in a continuous cross-flow in a molded microfluidic device

V VanDelinder, A Groisman - Analytical chemistry, 2006 - ACS Publications
We designed, fabricated, and tested a microfluidic device for separation of plasma from whole
human blood by size exclusion in a cross-flow. The device is made of a single mold of a …

A microfluidic rectifier: Anisotropic flow resistance at low Reynolds numbers

A Groisman, SR Quake - Physical review letters, 2004 - APS
It is one of the basic concepts of Newtonian fluid dynamics that at low Reynolds number (Re)
the Navier-Stokes equation is linear and flows are reversible. In microfluidic devices, where …

Elastic turbulence in a polymer solution flow

A Groisman, V Steinberg - Nature, 2000 - nature.com
Turbulence is a ubiquitous phenomenon that is not fully understood. It is known that the flow
of a simple, newtonian fluid is likely to be turbulent when the Reynolds number is large (…

[HTML][HTML] Self-organization in high-density bacterial colonies: efficient crowd control

…, JW Williams, B Jedynak, AM Stevens, A Groisman… - PLoS …, 2007 - journals.plos.org
Colonies of bacterial cells can display complex collective dynamics, frequently culminating in
the formation of biofilms and other ordered super-structures. Recent studies suggest that to …

Chaotic flow and efficient mixing in a microchannel with a polymer solution

T Burghelea, E Segre, I Bar-Joseph, A Groisman… - Physical Review E, 2004 - APS
Microscopic flows are almost universally linear, laminar, and stationary because the Reynolds
number, Re, is usually very small. That impedes mixing in microfluidic devices, which …

High-throughput and high-resolution flow cytometry in molded microfluidic devices

C Simonnet, A Groisman - Analytical chemistry, 2006 - ACS Publications
We describe the design, fabrication, and operation of two types of flow cytometers based on
microfluidic devices made of a single cast of poly(dimethylsiloxane). The stream of particles …

'Slings' enable neutrophil rolling at high shear

…, Y Kuwano, S Fukuda, MK Pospieszalska, A Groisman… - Nature, 2012 - nature.com
Most leukocytes can roll along the walls of venules at low shear stress (1 dyn cm −2 ), but
neutrophils have the ability to roll at tenfold higher shear stress in microvessels in vivo 1 , 2 . …