User profiles for Alex Groisman
Alex GroismanUCSD, Physics Verified email at ucsd.edu Cited by 12188 |
Microfluidic memory and control devices
A Groisman, M Enzelberger, SR Quake - Science, 2003 - science.org
We demonstrate microscopic fluidic control and memory elements through the use of an
aqueous viscoelastic polymer solution as a working fluid. By exploiting the fluid's non-…
aqueous viscoelastic polymer solution as a working fluid. By exploiting the fluid's non-…
MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast
The mating pathway in Saccharomyces cerevisiae has been the focus of considerable
research effort, yet many quantitative aspects of its regulation still remain unknown. Using an …
research effort, yet many quantitative aspects of its regulation still remain unknown. Using an …
A microfluidic chemostat for experiments with bacterial and yeast cells
A Groisman, C Lobo, HJ Cho, JK Campbell… - Nature …, 2005 - nature.com
Bacteria and yeast frequently exist as populations capable of reaching extremely high cell
densities. With conventional culturing techniques, however, cell proliferation and ultimate …
densities. With conventional culturing techniques, however, cell proliferation and ultimate …
Separation of plasma from whole human blood in a continuous cross-flow in a molded microfluidic device
V VanDelinder, A Groisman - Analytical chemistry, 2006 - ACS Publications
We designed, fabricated, and tested a microfluidic device for separation of plasma from whole
human blood by size exclusion in a cross-flow. The device is made of a single mold of a …
human blood by size exclusion in a cross-flow. The device is made of a single mold of a …
A microfluidic rectifier: Anisotropic flow resistance at low Reynolds numbers
A Groisman, SR Quake - Physical review letters, 2004 - APS
It is one of the basic concepts of Newtonian fluid dynamics that at low Reynolds number (Re)
the Navier-Stokes equation is linear and flows are reversible. In microfluidic devices, where …
the Navier-Stokes equation is linear and flows are reversible. In microfluidic devices, where …
Elastic turbulence in a polymer solution flow
A Groisman, V Steinberg - Nature, 2000 - nature.com
Turbulence is a ubiquitous phenomenon that is not fully understood. It is known that the flow
of a simple, newtonian fluid is likely to be turbulent when the Reynolds number is large (…
of a simple, newtonian fluid is likely to be turbulent when the Reynolds number is large (…
[HTML][HTML] Self-organization in high-density bacterial colonies: efficient crowd control
Colonies of bacterial cells can display complex collective dynamics, frequently culminating in
the formation of biofilms and other ordered super-structures. Recent studies suggest that to …
the formation of biofilms and other ordered super-structures. Recent studies suggest that to …
Chaotic flow and efficient mixing in a microchannel with a polymer solution
Microscopic flows are almost universally linear, laminar, and stationary because the Reynolds
number, Re, is usually very small. That impedes mixing in microfluidic devices, which …
number, Re, is usually very small. That impedes mixing in microfluidic devices, which …
High-throughput and high-resolution flow cytometry in molded microfluidic devices
C Simonnet, A Groisman - Analytical chemistry, 2006 - ACS Publications
We describe the design, fabrication, and operation of two types of flow cytometers based on
microfluidic devices made of a single cast of poly(dimethylsiloxane). The stream of particles …
microfluidic devices made of a single cast of poly(dimethylsiloxane). The stream of particles …
'Slings' enable neutrophil rolling at high shear
…, Y Kuwano, S Fukuda, MK Pospieszalska, A Groisman… - Nature, 2012 - nature.com
Most leukocytes can roll along the walls of venules at low shear stress (1 dyn cm −2 ), but
neutrophils have the ability to roll at tenfold higher shear stress in microvessels in vivo 1 , 2 . …
neutrophils have the ability to roll at tenfold higher shear stress in microvessels in vivo 1 , 2 . …