Regulation of glial activation and neuroinflammation are critical factors in the pathogenesis
of Alzheimer’s disease (AD). YKL-40, a primarily astrocytic protein encoded by the gene …

The expansion of the GGGGCC hexanucleotide repeat in the non-coding region of the
Chromosome 9 open-reading frame 72 (C9orf72) gene is the most common genetic cause of …

Cellular heterogeneity confounds in situ assays of transcription factor (TF) binding. Single-cell
RNA sequencing (scRNA-seq) deconvolves cell types from gene expression, but no …

Amputation of the digit tip within the terminal phalangeal bone of rodents, monkeys, and
humans results in near‐perfect regeneration of bone and surrounding tissues; however, …

Oxygen is critical for optimal bone regeneration. While axolotls and salamanders have retained
the ability to regenerate whole limbs, mammalian regeneration is restricted to the distal …

Objective To define the natural history of the C9orf72 amyotrophic lateral sclerosis (C9ALS)
patient population, develop disease biomarkers, and characterize patient pathologies. …

Transcription factors (TFs) enact precise regulation of gene expression through site-specific,
genome-wide binding. Common methods for TF-occupancy profiling, such as chromatin …

Calling Cards is a platform technology to record a cumulative history of transient protein‐DNA
interactions in the genome of genetically targeted cell types. The record of these …

The most common genetic cause of both frontotemporal dementia (FTD) and amyotrophic
lateral sclerosis (ALS) is a G4C2 repeat expansion in intron 1 of the C9orf72 gene. This repeat …

We report a conserved transcriptomic signature of reduced fatty acid and lipid metabolism
gene expression in human post-mortem ALS spinal cord and a Drosophila model of the most …