The shape of motile cells is determined by many dynamic processes spanning several
orders of magnitude in space and time, from local polymerization of actin monomers at …

Much of current understanding of cell motility arose from studying steady treadmilling of actin
arrays. Recently, there have been a growing number of observations of a more complex, …

Mathematical and computational modeling is rapidly becoming an essential research technique
complementing traditional experimental biological methods. However, lack of standard …

In creating the mitotic spindle and the contractile ring, natural selection has engineered
fascinating precision machines whose movements depend upon forces generated by ensembles …

Using two-colour imaging and high resolution TIRF microscopy, we investigated the assembly
and maturation of nascent adhesions in migrating cells. We show that nascent adhesions …

A migrating cell is a molecular machine made of tens of thousands of short-lived and
interacting parts. Understanding migration means understanding the self-organization of these …

The lamellipod, the locomotory region of migratory cells, is shaped by the balance of
protrusion and contraction. The latter is the result of myosin-generated centripetal flow of the …

This paper develops a method for appraising health status in elderly people. A frailty index
was defined as the proportion of accumulated deficits (symptoms, signs, functional …

The cell is a mechanical machine, and continuum mechanics of the fluid cytoplasm and the
viscoelastic deforming cytoskeleton play key roles in cell physiology. We review …

Keratocytes are fast-moving cells in which adhesion dynamics are tightly coupled to the actin
polymerization motor that drives migration, resulting in highly coordinated cell movement. …