[HTML][HTML] Mutational spectrum, copy number changes, and outcome: results of a sequencing study of patients with newly diagnosed myeloma
…, EM Boyle, CP Wardell, A Murison… - Journal of clinical …, 2015 - ncbi.nlm.nih.gov
Purpose At the molecular level myeloma is characterised by copy number abnormalities
and recurrent translocations into the immunoglobulin heavy chain (IGH) locus. Novel …
and recurrent translocations into the immunoglobulin heavy chain (IGH) locus. Novel …
[HTML][HTML] APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma
We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study
using whole exome sequencing. Here we identify mutations induced as a consequence of …
using whole exome sequencing. Here we identify mutations induced as a consequence of …
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies
…, S Remeseiro, N Takayama, SW Ng, A Murison… - Nature, 2018 - nature.com
The transcription factor Myc is essential for the regulation of haematopoietic stem cells and
progenitors and has a critical function in haematopoietic malignancies 1 . Here we show that …
progenitors and has a critical function in haematopoietic malignancies 1 . Here we show that …
Genomic hallmarks of localized, non-indolent prostate cancer
…, M Orain, V Picard, H Hovington, A Murison… - Nature, 2017 - nature.com
Prostate tumours are highly variable in their response to therapies, but clinically available
prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 …
prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 …
Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia
Lineage-ambiguous leukemias pose significant diagnostic and therapeutic challenges due
to a poorly understood molecular and cellular basis. We identify oncogenic deregulation of …
to a poorly understood molecular and cellular basis. We identify oncogenic deregulation of …
[PDF][PDF] The proteogenomic landscape of curable prostate cancer
DNA sequencing has identified recurrent mutations that drive the aggressiveness of
prostate cancers. Surprisingly, the influence of genomic, epigenomic, and transcriptomic …
prostate cancers. Surprisingly, the influence of genomic, epigenomic, and transcriptomic …
[PDF][PDF] TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate
…, KB Kaufmann, F Schneiter, V Voisin, A Murison… - Cell stem cell, 2021 - cell.com
It is critical to understand how human quiescent long-term hematopoietic stem cells (LT-HSCs)
sense demand from daily and stress-mediated cues and then transition into …
sense demand from daily and stress-mediated cues and then transition into …
Epigenetic switch–induced viral mimicry evasion in chemotherapy-resistant breast cancer
…, X Liu, P Guilhamon, E Lima-Fernandes, A Murison… - Cancer discovery, 2020 - AACR
Drug-resistant cancer cells represent a major barrier to remission for patients with cancer.
Here we show that drug-induced metabolic perturbation and epigenetic states enable evasion …
Here we show that drug-induced metabolic perturbation and epigenetic states enable evasion …
[PDF][PDF] MLL5 orchestrates a cancer self-renewal state by repressing the histone variant H3. 3 and globally reorganizing chromatin
Mutations in the histone 3 variant H3.3 have been identified in one-third of pediatric glioblastomas
(GBMs), but not in adult tumors. Here we show that H3.3 is a dynamic determinant of …
(GBMs), but not in adult tumors. Here we show that H3.3 is a dynamic determinant of …
The spectrum and clinical impact of epigenetic modifier mutations in myeloma
…, C Heuck, L Melchor, CP Wardell, A Murison… - Clinical cancer …, 2016 - AACR
Purpose: Epigenetic dysregulation is known to be an important contributor to myeloma
pathogenesis but, unlike other B-cell malignancies, the full spectrum of somatic mutations in …
pathogenesis but, unlike other B-cell malignancies, the full spectrum of somatic mutations in …