Patients with densely innervated tumors suffer with increased metastasis and decreased
survival as compared to those with less innervated tumors. We hypothesize that in some tumors…

Due to the prevalence of cardiovascular diseases, there is a large need for small diameter
vascular grafts that cannot be fulfilled using autologous vessels. Although medium to large …

Despite significant progress over the past few decades, creating a tissue-engineered
vascular graft with replicated functions of native blood vessels remains a challenge due to the …

Vascular smooth muscle cell (VSMC) migration is a critical step in the progression of
cardiovascular disease and aging. Migrating VSMCs encounter a highly heterogeneous …

Aims Cholesterol not only deposits in foam cells at the atherosclerotic plaque, but also plays
an important role as a regulator of cell migration in atherogenesis. In addition, the …

Pectin nanofiber mats are promising tissue engineering scaffolds but suffer from poor cell
infiltration. In this study, gelatin, a collagen derived cell adhesive protein, was used to crosslink …

Key points This study demonstrates and evaluates the changes in rat vascular smooth muscle
cell biomechanics following statin‐mediated cholesterol depletion. Evidence is presented …

Although a significant number of studies on vascular tissue engineering have been reported,
the current availability of vessel substitutes in the clinic remains limited mainly due to the …

Atherosclerosis-related cardiovascular diseases are a leading cause of mortality worldwide.
Vascular smooth muscle cells (VSMCs) comprise the medial layer of the arterial wall and …

Cardiovascular disease (CVD) remains the primary cause of death worldwide. Specifically,
atherosclerosis is a CVD characterized as a slow progressing chronic inflammatory disease. …