Background Large language models (LLMs) have recently shown impressive zero-shot
capabilities, whereby they can use auxiliary data, without the availability of task-specific training …

Background: The role of increased smooth muscle cell (SMC) integrin αv signaling in Marfan
syndrome (MFS) aortic aneurysm remains unclear. Herein, we examine the mechanism …

Objective— Rupture and dissection of aortic root aneurysms remain the leading causes of
death in patients with the Marfan syndrome, a hereditary connective tissue disorder that …

Background: Aortic root smooth muscle cells (SMC) develop from both the second heart field
(SHF) and neural crest. Disparate responses to disease-causing Fbn1 variants by these …

BACKGROUND: The application of single-cell transcriptomic (single-cell RNA sequencing)
analysis to the study of atherosclerosis has provided unique insights into the molecular and …

Limited aortic root repair for acute type A dissection is associated with greater risk of proximal
reoperations compared to full aortic root replacement. Surgical outcomes for patients …

Aortic root aneurysm formation and subsequent dissection and/or rupture remain the leading
cause of death in patients with Marfan syndrome. Our laboratory has reported that miR‐29b …

Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the FBN1
gene that produces wide disease phenotypic variability. The lack of ample genotype–…

Background: Smooth muscle cell (SMC) phenotypic reprogramming toward a mixed
synthetic-proteolytic state is a central feature of aortic root aneurysm in Marfan syndrome (MFS). …

Background— Ascending aortic dissection and rupture remain a life-threatening complication
in patients with Marfan syndrome. The extracellular matrix provides strength and elastic …