User profiles for Alex Tuck
 | Alex TuckSOPHiA GENETICS SA Verified email at sophiagenetics.com Cited by 1718 |
[PDF][PDF] Single cell RNA-sequencing of pluripotent states unlocks modular transcriptional variation
Embryonic stem cell (ESC) culture conditions are important for maintaining long-term self-renewal,
and they influence cellular pluripotency state. Here, we report single cell RNA-…
and they influence cellular pluripotency state. Here, we report single cell RNA-…
[HTML][HTML] A transcriptome-wide atlas of RNP composition reveals diverse classes of mRNAs and lncRNAs
AC Tuck, D Tollervey - Cell, 2013 - cell.com
Eukaryotic genomes generate a heterogeneous ensemble of mRNAs and long noncoding
RNAs (lncRNAs). LncRNAs and mRNAs are both transcribed by Pol II and acquire 5′ caps …
RNAs (lncRNAs). LncRNAs and mRNAs are both transcribed by Pol II and acquire 5′ caps …
[PDF][PDF] Transcriptome-wide analysis of exosome targets
The exosome plays major roles in RNA processing and surveillance but the in vivo target
range and substrate acquisition mechanisms remain unclear. Here we apply in vivo RNA …
range and substrate acquisition mechanisms remain unclear. Here we apply in vivo RNA …
RNA in pieces
AC Tuck, D Tollervey - Trends in genetics, 2011 - cell.com
Eukaryotic genomes accommodate numerous types of information within diverse DNA and
RNA sequence elements. At many loci, these elements overlap and the same sequence is …
RNA sequence elements. At many loci, these elements overlap and the same sequence is …
[PDF][PDF] Mammalian RNA decay pathways are highly specialized and widely linked to translation
RNA decay is crucial for mRNA turnover and surveillance and misregulated in many diseases.
This complex system is challenging to study, particularly in mammals, where it remains …
This complex system is challenging to study, particularly in mammals, where it remains …
[PDF][PDF] Nuclear RNA decay pathways aid rapid remodeling of gene expression in yeast
In budding yeast, the nuclear RNA surveillance system is active on all pre-mRNA transcripts
and modulated by nutrient availability. To test the role of nuclear surveillance in …
and modulated by nutrient availability. To test the role of nuclear surveillance in …
Reconstitution and analysis of the multienzyme Escherichia coli RNA degradosome
The Escherichia coli RNA degradosome is a multienzyme assembly that functions in transcript
turnover and maturation of structured RNA precursors. We have developed a procedure …
turnover and maturation of structured RNA precursors. We have developed a procedure …
Distinctive features of lincRNA gene expression suggest widespread RNA-independent functions
Eukaryotic genomes produce RNAs lacking protein-coding potential, with enigmatic roles.
We integrated three approaches to study large intervening noncoding RNA (lincRNA) gene …
We integrated three approaches to study large intervening noncoding RNA (lincRNA) gene …
Strand‐specific, high‐resolution mapping of modified RNA polymerase II
…, VA Huynh‐Thu, C Delan‐Forino, A Tuck… - Molecular systems …, 2016 - embopress.org
Reversible modification of the RNAP II C‐terminal domain links transcription with RNA
processing and surveillance activities. To better understand this, we mapped the location of …
processing and surveillance activities. To better understand this, we mapped the location of …
The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1
TRIM71/LIN-41, a phylogenetically conserved regulator of development, controls stem cell
fates. Mammalian TRIM71 exhibits both RNA-binding and protein ubiquitylation activities, but …
fates. Mammalian TRIM71 exhibits both RNA-binding and protein ubiquitylation activities, but …