When networks walk a fine line: balance of excitation and inhibition in spinal motor circuits

RW Berg, A Willumsen, H Lindén - Current Opinion in Physiology, 2019 - Elsevier
Highlights • Balanced networks are widespread in the brain, yet their role in the spinal cord
is unclear. • Respiratory and lumbar circuits show signs of balanced activity. • Network motifs …

[HTML][HTML] Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord

M Radosevic, A Willumsen, PC Petersen… - Nature …, 2019 - nature.com
During the generation of rhythmic movements, most spinal neurons receive an oscillatory
synaptic drive. The neuronal architecture underlying this drive is unknown, and the …

Local networks from different parts of the human cerebral cortex generate and share the same population dynamic

A Willumsen, J Midtgaard, B Jespersen… - Cerebral cortex …, 2022 - academic.oup.com
A major goal of neuroscience is to reveal mechanisms supporting collaborative actions of
neurons in local and larger-scale networks. However, no clear overall principle of operation …

Human cerebral cortex networks use expanding and contracting state dynamic to shape cortical functions

A Willumsen, J Midtgaard, B Jespersen, CKK Hansen… - bioRxiv, 2020 - biorxiv.org
We lack viable explanations of how collective activities of neurons in networks produce brain
functions. We recorded field potentials from many local networks in the human cerebral …

[PDF][PDF] Cortical field potential dynamic driving human sensory, motor and cognitive functions

A Willumsen, J Midtgaard, B Jespersen, CKK Hansen… - scholar.archive.org
We lack viable explanations of how collective activities of neurons in networks produce brain
functions. We recorded field potentials from many local networks in the human cerebral …

PRIMA-1Met/APR-246 Induces Apoptosis and Tumor Growth Delay in Small Cell Lung Cancer Expressing Mutant p53

…, CL Christensen, TA Gerds, BM Willumsen… - Clinical Cancer …, 2011 - AACR
Purpose: Small cell lung cancer (SCLC) is a highly malignant disease with poor prognosis,
necessitating the need to develop new and efficient treatment modalities. PRIMA-1 Met (p53-…

The p21 ras C-terminus is required for transformation and membrane association

BM Willumsen, A Christensen, NL Hubbert… - Nature, 1984 - nature.com
The Harvey murine sarcoma virus (Ha-MuSV) transforming gene, v-ras H , encodes a 21,000
molecular weight protein (p21) that is closely related to the p21 proteins encoded by the …

The Chicxulub asteroid impact and mass extinction at the Cretaceous-Paleogene boundary

…, V Vajda, MT Whalen, PS Willumsen - science, 2010 - science.org
The Cretaceous-Paleogene boundary ~65.5 million years ago marks one of the three largest
mass extinctions in the past 500 million years. The extinction event coincided with a large …

Mutational analysis of a ras catalytic domain

BM Willumsen, AG Papageorge, HF Kung… - … and cellular biology, 1986 - Am Soc Microbiol
We used linker insertion-deletion mutagenesis to study the catalytic domain of the Harvey
murine sarcoma virus v-ras H transforming protein, which is closely related to the cellular ras H …

[HTML][HTML] The cost of inaction on physical inactivity to public health-care systems: a population-attributable fraction analysis

AC Santos, J Willumsen, F Meheus, A Ilbawi… - The Lancet Global …, 2023 - thelancet.com
Background Physical inactivity is an important modifiable risk factor for non-communicable
diseases (NCDs) and mental health conditions. We aimed to estimate the public health-care …