The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development
…, KI Sheridan, CC Warzecha, BW Cieply, AM Rohacek… - Elife, 2015 - elifesciences.org
10.7554/eLife.08954.001 Tissue- and cell-type-specific regulators of alternative splicing (AS)
are essential components of posttranscriptional gene regulation, necessary for normal …
are essential components of posttranscriptional gene regulation, necessary for normal …
[PDF][PDF] ESRP1 mutations cause hearing loss due to defects in alternative splicing that disrupt cochlear development
AM Rohacek, TW Bebee, RK Tilton, CM Radens… - Developmental cell, 2017 - cell.com
Alternative splicing contributes to gene expression dynamics in many tissues, yet its role in
auditory development remains unclear. We performed whole-exome sequencing in …
auditory development remains unclear. We performed whole-exome sequencing in …
[PDF][PDF] Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing
In mammals, sound is detected by mechanosensory hair cells that are activated in response
to vibrations at frequency-dependent positions along the cochlear duct. We demonstrate …
to vibrations at frequency-dependent positions along the cochlear duct. We demonstrate …
Genomic architecture of Shh-dependent cochlear morphogenesis
V Muthu, AM Rohacek, Y Yao, SM Rakowiecki… - …, 2019 - journals.biologists.com
The mammalian cochlea develops from a ventral outgrowth of the otic vesicle in response to
Shh signaling. Mouse embryos lacking Shh or its essential signal transduction components …
Shh signaling. Mouse embryos lacking Shh or its essential signal transduction components …
[HTML][HTML] Motivated displacement assay distinguishes ALA neuron mutants from RIS neuron mutants during recovery from heat stress in Caenorhabditis elegans
The interneurons ALA and RIS both regulate stress induced sleep in C. elegans but their roles
in awake animal movement has been reported to differ. We describe the development of a …
in awake animal movement has been reported to differ. We describe the development of a …
Discovering Novel Hearing Loss Genes: Roles For Esrp1 And Gas2 In Inner Ear Development And Auditory Function
AM Rohacek - 2018 - search.proquest.com
Hearing loss is the most common form of congenital birth defect, affecting an estimated 35
million children worldwide. To date, nearly 100 genes have been identified which contribute to …
million children worldwide. To date, nearly 100 genes have been identified which contribute to …
[PDF][PDF] PFS+ ECE: The state of the science on early childhood interventions
M Rohacek, E Greenberg, M Massey - 2016 - urban.org
Background Over the past several decades, major scientific advances have improved our
understanding of brain development as a systematic, incremental process that begins …
understanding of brain development as a systematic, incremental process that begins …
[PDF][PDF] The state of the science on early childhood interventions
M Rohacek, E Greenberg, M Massey - Pay for Success Early …, 2016 - pfs.urban.org
Background Over the past several decades, major scientific advances have improved our
understanding of brain development as a systematic, incremental process that begins …
understanding of brain development as a systematic, incremental process that begins …
[HTML][HTML] Extrapulmonary tuberculosis in HIV-infected patients in rural Tanzania: The prospective Kilombero and Ulanga antiretroviral cohort
Background In sub-Saharan Africa, diagnosis and management of extrapulmonary tuberculosis
(EPTB) in people living with HIV (PLHIV) remains a major challenge. This study aimed to …
(EPTB) in people living with HIV (PLHIV) remains a major challenge. This study aimed to …
[HTML][HTML] The Chronic Diseases Clinic of Ifakara (CDCI)—Establishing a Model Clinic for Chronic Care Delivery in Rural Sub-Saharan Africa
M Weisser, M Rohacek, R Ndege, E Luoga, A Katende… - Diseases, 2022 - mdpi.com
The rollout of antiretroviral drugs in sub-Saharan Africa to address the huge health impact of
the HIV pandemic has been one of the largest projects undertaken in medical history and is …
the HIV pandemic has been one of the largest projects undertaken in medical history and is …