Amyloid-β (Aβ) accumulation in senile plaques is a hallmark of Alzheimer’s disease (AD).
Immunotherapy is a leading approach for amyloid clearance, despite the early termination of …

Trigeminal neuralgia, historically dubbed the “suicide disease,” is an exceedingly painful
neurologic condition characterized by sudden episodes of intense facial pain. Unfortunately, …

Breast cancer is the second leading cause of death among women in the US. Targeted
therapies exist, however resistance is common and patients resort to chemotherapy. …

The clinical outcome of radiation therapy is restricted due to the acquired radio-resistance of
a subpopulation of tumour cells that may cause tumour relapse and distant metastasis. …

Radiotherapy remains a mainstay of treatment for a majority of cancer patients. We have
previously shown that the membrane bound matrix metalloproteinase MT1-MMP confers radio- …

As pyrazole and its derivatives have a wide range of biological activities, including anticancer
activity, the design of novel pyrazole derivatives has emerged as an important research …

We describe a microfluidic immunoassay device that permits sensitive and quantitative
multiplexed protein measurements on nano-liter-scale samples. The device exploits the …

Recurrent ovarian cancer (OvCa) is thought to result in part from the inability to eliminate rare
quiescent cancer stem cells (CSCs) that survive cytotoxic chemotherapy and drive tumor …

Proton therapy offers a distinct physical advantage over conventional X-ray therapy, but its
biological advantages remain understudied. In this study, we aimed to identify genetic factors …

Background Currently it is unclear how in situ breast cancer progresses to invasive disease;
therefore, a better understanding of the events that occur during the transition to invasive …