The clinical use of molecular targeted therapy is rapidly evolving but has primarily focused on
genomic alterations. Transcriptomic analysis offers an opportunity to dissect the complexity …

Cellular deconvolution algorithms virtually reconstruct tissue composition by analyzing the
gene expression of complex tissues. We present the decision tree machine learning algorithm…

In a translational relevant transcriptomic-based classification, we characterized the
microenvironment as a critical component of the B-cell lymphoma biology and associated it with the …

We have characterized the FL-infiltrating T cells, identified cytotoxic CD4 T cells as an important
component that is associated with tumor cell–intrinsic characteristics, and identified sets …

Signaling via Toll-like receptor 4 (TLR4) in macrophages constitutes an essential part of the
innate immune response to bacterial infections. Detailed and quantified descriptions of …

Despite a characteristic indolent course, a substantial subset of follicular lymphoma (FL)
patients has an early relapse with a poor outcome. Cells in the microenvironment may be a key …

Background Previously we demonstrated that the resection of primary 4T1 tumors only
slightly prolongs mouse survival, but importantly, creates a “window of opportunity” with …

Reference atlases, molecular and spatial maps of mammalian tissues, are critical resources
for discovery efforts and translational research. Their utility is dependent on operationalizing …

To avoid outbreaks of influenza virus epidemics and pandemics among human populations,
modern medicine requires the development of new universal vaccines that are able to …

Purpose: Multiparametric MRI (mpMRI) has become an indispensable radiographic tool in
diagnosing prostate cancer. However, mpMRI fails to visualize approximately 15% of clinically …