Epstein–Barr virus reprograms human B lymphocytes immediately in the prelatent phase of infection
P Mrozek-Gorska, A Buschle, D Pich… - Proceedings of the …, 2019 - National Acad Sciences
Epstein–Barr virus (EBV) is a human tumor virus and a model of herpesviral latency. The virus
efficiently infects resting human B lymphocytes and induces their continuous proliferation …
efficiently infects resting human B lymphocytes and induces their continuous proliferation …
[HTML][HTML] Epigenetic lifestyle of Epstein-Barr virus
A Buschle, W Hammerschmidt - Seminars in immunopathology, 2020 - Springer
Epstein-Barr virus (EBV) is a model of herpesvirus latency and epigenetic changes. The
virus preferentially infects human B-lymphocytes (and also other cell types) but does not turn …
virus preferentially infects human B-lymphocytes (and also other cell types) but does not turn …
MicroRNAs of Epstein-Barr virus control innate and adaptive antiviral immunity
M Albanese, T Tagawa, A Buschle… - Journal of …, 2017 - Am Soc Microbiol
Epstein-Barr virus (EBV) has established lifelong infection in more than 90% of humanity.
While infection is usually controlled by the immune system, the human host fails to completely …
While infection is usually controlled by the immune system, the human host fails to completely …
Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones
N Kirstein, A Buschle, X Wu, S Krebs, H Blum… - Elife, 2021 - elifesciences.org
Eukaryotic DNA replication initiates during S phase from origins that have been licensed in
the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, …
the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, …
BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBV
…, P Mrozek-Gorska, A Buschle… - Life Science …, 2019 - life-science-alliance.org
A hallmark of EBV infections is its latent phase, when all viral lytic genes are repressed.
Repression results from a high nucleosome occupancy and epigenetic silencing by cellular …
Repression results from a high nucleosome occupancy and epigenetic silencing by cellular …
[HTML][HTML] Highly efficient CRISPR-Cas9-mediated gene knockout in primary human B cells for functional genetic studies of Epstein-Barr virus infection
E Akidil, M Albanese, A Buschle, A Ruhle, D Pich… - PLoS …, 2021 - journals.plos.org
Gene editing is now routine in all prokaryotic and metazoan cells but has not received much
attention in immune cells when the CRISPR-Cas9 technology was introduced in the field of …
attention in immune cells when the CRISPR-Cas9 technology was introduced in the field of …
Epstein-Barr virus inactivates the transcriptome and disrupts the chromatin architecture of its host cell in the first phase of lytic reactivation
A Buschle, P Mrozek-Gorska… - Nucleic acids …, 2021 - academic.oup.com
Epstein-Barr virus (EBV), a herpes virus also termed HHV 4 and the first identified human
tumor virus, establishes a stable, long-term latent infection in human B cells, its preferred host. …
tumor virus, establishes a stable, long-term latent infection in human B cells, its preferred host. …
Structural basis of DNA methylation-dependent site selectivity of the Epstein–Barr virus lytic switch protein ZEBRA/Zta/BZLF1
…, J Günther, MF Oliva, A Buschle… - Nucleic acids …, 2022 - academic.oup.com
In infected cells, Epstein–Barr virus (EBV) alternates between latency and lytic replication.
The viral bZIP transcription factor ZEBRA (Zta, BZLF1) regulates this cycle by binding to two …
The viral bZIP transcription factor ZEBRA (Zta, BZLF1) regulates this cycle by binding to two …
Human ORC/MCM density is low in active genes and correlates with replication time but does not solely define replication initiation zones
N Kirstein, A Buschle, X Wu, S Krebs, H Blum… - bioRxiv, 2020 - biorxiv.org
Eukaryotic DNA replication initiates during S phase from origins that have been licensed in
the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, …
the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, …
Active transcription regulates ORC/MCM distribution whereas replication timing correlates with ORC density in human cells
N Kirstein, A Buschle, X Wu, S Krebs, H Blum… - bioRxiv, 2019 - biorxiv.org
Eukaryotic replication initiates during S phase from origins that have been licensed in the
preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, …
preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, …