User profiles for Alexander D. Edwards
 | Alexander EdwardsAssociate Professor in Biomedical Technology, university of Southampton Verified email at southampton.ac.uk Cited by 4856 |
[PDF][PDF] Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins
Pattern-recognition receptors (PRRs) detect molecular signatures of microbes and initiate
immune responses to infection. Prototypical PRRs such as Toll-like receptors (TLRs) signal via …
immune responses to infection. Prototypical PRRs such as Toll-like receptors (TLRs) signal via …
Toll‐like receptor expression in murine DC subsets: lack of TLR7 expression by CD8α+ DC correlates with unresponsiveness to imidazoquinolines
AD Edwards, SS Diebold, EMC Slack… - European journal of …, 2003 - Wiley Online Library
Toll‐like receptors (TLR) recognize microbial and viral patterns and activate dendritic cells (DC).
TLR distribution among human DC subsets is heterogeneous: plasmacytoid DC (PDC) …
TLR distribution among human DC subsets is heterogeneous: plasmacytoid DC (PDC) …
[PDF][PDF] CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal
CD40 ligation triggers IL-12 production by dendritic cells (DC) in vitro. Here, we demonstrate
that CD40 cross-linking alone is not sufficient to induce IL-12 production by DC in vivo. …
that CD40 cross-linking alone is not sufficient to induce IL-12 production by DC in vivo. …
Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages
J Herre, ASJ Marshall, E Caron, AD Edwards… - Blood, 2004 - ashpublications.org
The phagocytosis of pathogens is a critical event in host defense, not only for clearance of
the invading microorganism, but also for the subsequent immune response. We have …
the invading microorganism, but also for the subsequent immune response. We have …
[HTML][HTML] Portable smartphone quantitation of prostate specific antigen (PSA) in a fluoropolymer microfluidic device
AI Barbosa, P Gehlot, K Sidapra, AD Edwards… - Biosensors and …, 2015 - Elsevier
We present a new, power-free and flexible detection system named MCFphone for portable
colorimetric and fluorescence quantitative sandwich immunoassay detection of prostate …
colorimetric and fluorescence quantitative sandwich immunoassay detection of prostate …
Microbial recognition via Toll-like receptor-dependent and-independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 …
AD Edwards, SP Manickasingham… - The Journal of …, 2002 - journals.aai.org
Dendritic cells (DC) can produce Th-polarizing cytokines and direct the class of the adaptive
immune response. Microbial stimuli, cytokines, chemokines, and T cell-derived signals all …
immune response. Microbial stimuli, cytokines, chemokines, and T cell-derived signals all …
Relationships among murine CD11chigh dendritic cell subsets as revealed by baseline gene expression patterns
AD Edwards, D Chaussabel, S Tomlinson… - The Journal of …, 2003 - journals.aai.org
The functional relationships and properties of different subtypes of dendritic cells (DC)
remain largely undefined. To better characterize these cells, we used global gene analysis to …
remain largely undefined. To better characterize these cells, we used global gene analysis to …
The ability of murine dendritic cell subsets to direct T helper cell differentiation is dependent on microbial signals
SP Manickasingham, AD Edwards… - European journal of …, 2003 - Wiley Online Library
Dendritic cells (DC) initiate T cell responses and direct the class of T cell immunity through
the production of Th‐polarizing cytokines. In the mouse, immunization with CD8α + DC has …
the production of Th‐polarizing cytokines. In the mouse, immunization with CD8α + DC has …
Austenitic stainless steels and high strength copper alloys for fusion components
…, JF Stubbins, DJ Edwards, DJ Alexander - Journal of nuclear …, 1998 - Elsevier
… Alexander and Gieseke reported a severe reduction in fracture toughness at 250C after
irradiation of a GlidCop Al15 alloy to only 0.3 dpa [24]. Data presented by Tähtinen et al. in these …
irradiation of a GlidCop Al15 alloy to only 0.3 dpa [24]. Data presented by Tähtinen et al. in these …
[HTML][HTML] A lab-in-a-briefcase for rapid prostate specific antigen (PSA) screening from whole blood
We present a new concept for rapid and fully portable prostate specific antigen (PSA)
measurements, termed “lab-in-a-briefcase”, which integrates an affordable microfluidic ELISA …
measurements, termed “lab-in-a-briefcase”, which integrates an affordable microfluidic ELISA …