DNA and RNA helicases are ubiquitous enzymes that mediate the nucleoside-triphosphate-dependent
unwinding of nucleic acid duplexes, a necessary step in genome replication, …

On the basis of similarities in their genome organization and replication strategy, RNA viruses
can now be classified into ‘supergroups’ that often include both animal and plant viruses (…

This review focuses on the monophyletic group of animal RNA viruses united in the order
Nidovirales. The order includes the distantly related coronaviruses, toroviruses, and roniviruses…

During the summer of 2012, in Jeddah, Saudi Arabia, a hitherto unknown coronavirus (CoV)
was isolated from the sputum of a patient with acute pneumonia and renal failure (1, 2). The …

The present outbreak of lower respiratory tract infections, including respiratory distress
syndrome, is the third spillover, in only two decades, of an animal coronavirus to humans …

The genome organization and expression strategy of the newly identified severe acute
respiratory syndrome coronavirus (SARS-CoV) were predicted using recently published genome …

In the course of systematic analysis of protein sequences containing the purine NTP-binding
motif, a new superfamily was delineated which included 25 established or putative …

A novel coronavirus is the causative agent of the current epidemic of severe acute respiratory
syndrome (SARS). Coronaviruses are exceptionally large RNA viruses and employ …

A novel human coronavirus (HCoV-EMC/2012) was isolated from a man with acute pneumonia
and renal failure in June 2012. This report describes the complete genome sequence, …

The number and diversity of viral sequences that are identified in metagenomic data far
exceeds that of experimentally characterized virus isolates. In a recent workshop, a panel of …